Depression and Pre-Clinical Dementia

Research Paper Title

A cross-national study of depression in preclinical dementia: A COSMIC collaboration study.


Depression commonly accompanies Alzheimer’s disease, but the nature of this association remains uncertain.


Longitudinal data from the COSMIC consortium were harmonized for eight population-based cohorts from four continents. Incident dementia was diagnosed in 646 participants, with a median follow-up time of 5.6 years to diagnosis. The association between years to dementia diagnosis and successive depressive states was assessed using a mixed effect logistic regression model. A generic inverse variance method was used to group study results, construct forest plots, and generate heterogeneity statistics.


A common trajectory was observed showing an increase in the incidence of depression as the time to dementia diagnosis decreased despite cross-national variability in depression rates.


The results support the hypothesis that depression occurring in the preclinical phases of dementia is more likely to be attributable to dementia-related brain changes than environment or reverse causality.


Carles, S., Carriere, I., Reppermund, S., Davin, A., Guaita, A., Vaccaro, R., Ganguli, M., Jacobsen, E.P., Beer, J.C., Riedel-Heller, S.G., Roehr, S., Pabst, A., Haan, M.N., Brodarty, H., Kochan, N.A., Trollor, J.N., Kim, K.W., Han, J.W., Suh, S.W., Lobo, A., De La Camara, C., Lobo, E., Lipnicki, D.M., Sachdev, P.S., Ancelin, M-L., Ritchie, K. & for Cohrot Studies of Memory in an International Consortium (COSMIC). (2020) A cross-national study of depression in preclinical dementia: A COSMIC collaboration study. Alzheimer’s & Dementia. doi: 10.1002/alz.12149. Online ahead of print.

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