Introduction

Triazolobenzodiazepines (TBZD) are a class of benzodiazepine (BZD) derivative pharmaceutical drugs. Chemically, they differ from other benzodiazepines by having an additional fused triazole ring.

Examples include:

• Adinazolam.
• Alprazolam.
• Bromazolam.
• Clonazolam.
• Estazolam.
• Flualprazolam.
• Flubromazolam.
• Flunitrazolam.
• Nitrazolam.
• Pyrazolam.
• Triazolam.
• Zapizolam.

Synthesis

Synthesis of 1-methyltriazolobenzodiazepines (alprazolam type) is possible by heating 1,4-benzodiazepin-2-thiones with hydrazine and acetic acid in n-butanol under reflux.