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Is There a link between Separation Anxiety Trajectory in Early Childhood & Risk for Sleep Bruxism?

Research Paper Title

High separation anxiety trajectory in early childhood is a risk factor for sleep bruxism at age 7.

Background

The evolution of sleep bruxism manifestations and their co-occurrence with separation anxiety in early childhood remain unclear.

The researchers threefold aim was to:

  1. Describe developmental sleep bruxism trajectories in early childhood;
  2. Investigate co-occurrences between trajectories of sleep bruxism and separation anxiety; and
  3. Determine whether distinct trajectories of separation anxiety increase the risk of presenting sleep bruxism during the first year of elementary school.

Methods

This study is part of the Québec Longitudinal Study of Child Development.

Sleep bruxism scores were assessed from age 1.5 to 7 years with the Self-Administered Questionnaire for Mother (n=1,946).

Separation anxiety scores were measured from age 1.5 to 6 years with the Interviewer-Completed Computerised Questionnaire (n=2,045).

Results

The researchers identified:

  • Four sleep bruxism trajectories from age 1.5 to 6 years:
    • High-Increasing sleep bruxism at age 1.5 (14.1%);
    • High-Increasing sleep bruxism at age 4 (18.3%);
    • Low-Persistent sleep bruxism (12.1%); and
    • Never-Persistent sleep bruxism (55.5%).
  • Four separation anxiety trajectories from age 1.5 to 6 years:
    • Low-Persistent separation anxiety (60.2%);
    • High-Increasing separation anxiety (6.9%);
    • High-Decreasing separation anxiety (10.8%); and
    • Low-Increasing separation anxiety (22.1%).

Sleep bruxism and separation anxiety trajectories were weakly associated (X2=37.84, P<0.001).

Compared with preschoolers belonging to the Low-Persistent separation anxiety trajectory, preschoolers in the High-Increasing separation anxiety trajectory had almost double the risk of presenting sleep bruxism at age 7 (95% CI=1.25-3.22, P=.04).

Conclusions

When separation anxiety issues are detected in early childhood, it would be useful to target sleep bruxism during the first year of elementary school.

Reference

Rostami, E.G., Touchette, É., Huynh, N., Montplaisir, J., Tremblay, R.E., Battaglia, M. & Boivin, M. (2020) High separation anxiety trajectory in early childhood is a risk factor for sleep bruxism at age 7.

Reviewing Work & Mental Health in Doctors

Research Paper Title

Work and Mental Health in Doctors: A Short Review of Norwegian Studies.

Background

Previous studies have found relatively good physical health in doctors, whereas several studies now report relatively high levels of mental distress among them. This applies in particular to stress, burnout, and depressive symptoms – and especially among medical students and young doctors early in their careers. However, we lack representative prevalence studies of mental disorders among doctors. There is little empirical support for the notion that there is more mental distress in medical students compared to that in other university students, nor do they differ from other students with respect to personality traits.

Despite this, several studies have found more suicide among physicians than in other occupational groups. This may be partly due to their attempts in committing suicide being more frequently successful; yet, this may also represent the tip of an iceberg of frustration and inadequate mental health care among medical doctors.

Presumed Risk Factors from Longitudinal Studies

What do we know about individual and work-related predictors and risk factors of mental distress from the prospective and longitudinal studies so far? Some landmark early follow-up studies in the United States and United Kingdom put doctors’ work and mental health on the agenda in the 1970’s and 1980’s. In the following, we will pay most attention to the Longitudinal Study of Norwegian Medical Students and Doctors (NORDOC). This study has since 1993/1994 followed repeatedly 2 cohorts of medical students (N = 1052) with 6 years apart for 20 years (2014), and there is now an ongoing 25-year follow up.

There are 2 main hypotheses with regard to possible risks factors. First, it may be due to individual factors such as personality traits, past mental health problems, etc. Second, contextual stress may influence mental health among doctors, whether this is unhealthy working conditions or negative life events (i.e., stress outside of work). Both individual and work-related factors seem to be of importance. Individual factors may be more important with respect to more severe clinical mental disorders, whereas work-related factors are more important for stress, burnout, and minor emotional disturbance.

In terms of individual factors, NORDOC has included personality traits, as one of very few studies in doctors. Neuroticism personality trait is related to vulnerability, self-criticism, low self-esteem, and proneness to stress compatible with the modern common term “hypersensitivity.” This trait predicts stress, anxiety, and depression in the general population, and, as expected, in NORDOC it predicts work stress, burnout, and even severe depressive symptoms among doctors. Studies among medical students and young doctors have found the combination of conscientiousness (or obsessiveness) and neuroticism seems to be especially important for school and work stress. In addition, NORDOC has identified a particular trait (reality weakness) that is associated with severe personality pathology. This trait predicts independently a need for mental health treatment, lack of help-seeking, severe depressive symptoms, and even aggravation of suicidal ideation among medical students and doctors. Another important individual factor is the increased rate of female medical students and young doctors. In Norway, there has been an increase from 55% to 70% of women in medical schools during the past 2 decades. We have previously found little gender differences in NORDOC, but a recent study among Norwegian medical students find considerable reduction in subjective well-being in 2015 compared to that 20 years ago, and this reduction was most prominent among the female students. This reflects recent trends in Norway and other Western societies which observe increased anxiety and depressive symptoms among young female adults.

With regard to contextual stress, it seems that both work-related stress and stress outside of work are of importance. NORDOC studies have found that demanding patient work is associated with mental health problems early in the medical career, and that difficulty with balancing life – such as work–home interface stress – is a sustaining problem over the course of the career. The detrimental role of such stress is also in keeping with studies among US doctors. Work–home stress predicts burnout (emotional exhaustion) in a NORDOC 5-year follow-up study. A promising finding is that such stress was less prominent in the youngest cohort of Norwegian doctors 10 years after leaving medical school. This may be due to increased coverage of kindergarten as well as changed and more liberal gender roles in our Scandinavian society over recent years.

There are also studies that associate time pressures and burnout with suicidal ideation among medical students and doctors. Sleep-deprivation due to call work and long hours may be one important reason for more depressive symptoms measured in young doctors. A recent NORDOC study of life satisfaction during 15 years of the career controlled for all possible individual factors, and found the following work-related predictors and possible risk factors: work–home stress, lack of colleague support, and emotional demands at work. Doctors often feel a 24/7 responsibility and obligation for individual patients and their treatment and this puts extraordinary emotional demands on this occupational group.

Does Stress among Doctors have Consequences for their Patient Care?

Many studies can indicate lowered quality of patient care among stressed doctors with burnout, but a large majority of these studies build on self-report by the doctors themselves of more errors and poorer care. We lack an empirical foundation for the notion that stress and burnout really impair doctors’ functioning with respect to observed poorer quality of care. There are 2 classical observation studies demonstrating that long hours and time pressures interfere with doctors functioning, but we lack studies that find burnout to lead to observed errors or poorer care. The burnout concept and scales are not very valid with respect to impaired functioning, for example, with respect to valid cut-off for defining a case.38 On the other hand, depression and other mental disorders lead to poor functioning. We need more studies on working conditions and the levels of stress and poor health among young doctors that lead to lowered patient care.

What are the Most Common Mental Disorders among Doctors?

In general, doctors may have the same disorders that strike anyone else; doctors are not invincible. Although depressive symptoms seem to be prevalent in the early years of the medical career, some of this may be due to exhausting work stress by frequent on-call work. We lack representative studies on the occurrence of valid depression among doctors compared to that in other occupational groups. Suicide is more common among doctors than among other groups of academics, but since it is also very common in veterinarians, this may also be due to available knowledge and means (drugs) for committing suicide during mental health deterioration. Alcoholism and drug abuse is an additional known risk factor for suicide and the SAD triad (suicidal behaviour–alcoholism–depression) may be particularly important for medical doctors. From clinical experience with doctor–patients, we know the slippery slope from self-medication with tranquilisers to cope with the stresses to dependency of alcohol and drugs, in addition to other boundary violations. There are very few clinical studies including diagnostic interviews among doctors. One previous Spanish study emphasises the importance of dual diagnoses, especially in alcohol dependence and mood disorders. From own experience, we know that bipolar disorder (type II) is quite common among physicians, but we lack sound empirical studies that compare occurrence of mental disorders in doctors with that in other groups. American impaired physician programs have for many years shown high and promising recovery rates (70–80%). The programmes used to focus on addiction and substance abuse, but they now put increasing emphasis on psychiatric diagnoses. A family history, opioid use, and psychiatric comorbidity predicted relapse of substance abuse among doctors and other healthcare workers.

In Norway, we have implemented a successful low-threshold intervention, the Villa Sana programme. This intervention seems to reduce burnout in doctors. It includes 2 separate schemes, a 1-day individual counselling scheme, and a 1-week group-based scheme in a psychiatric hospital. The Norwegian Medical Association pays for the programme that is free for all doctors.

With respect to medical students and young doctors, we have also a large longitudinal study on mindfulness-based stress reduction. This is a randomised-controlled trial of second year medical and psychology students, and they have now been followed-up for 6 years, for the medical students into the first 2 postgraduate years. The reduction of emotional distress by mindfulness training is most prominent in female students.46 The training has a stronger impact among those with vulnerable personality (high neuroticism and conscientiousness). During the follow-up, there is an increase in active coping and reduction in passive or avoidance coping – the effects on ways of coping may be important psychological mechanisms of mindfulness training.

Future Research Challenges

We need more long-term follow-up studies that use validated instruments to capture changes in working conditions and their impact on physician health. For instance, there are few studies in doctors of Karasek’s Demand-Control model. There are more studies by this model in other healthcare workers. More studies are required that measure the effect of physicians’ health problems on their performance and patient care. Gender issues are important, since there are now more women entering the medical career. As mentioned, we also need more studies with diagnostic interviews that compare frequency of valid disorders in samples of physicians with that in other groups. Doctors are nowadays moving, and we should study the effect of globalisation on doctor’s health. Cross-national disparities may be due to differences in the health systems, working conditions, etc. Finally, we need more studies on positive psychology and factors that may promote and enhance well-being among physicians.

Reference

Tyssen, R. (2019) Work and Mental Health in Doctors: A Short Review of Norwegian Studies. Porto Biomedical Journal. 4(5), pp.e50. Published online 2019 Sep 9. doi: 10.1097/j.pbj.0000000000000050.

Why is it Important to Identify Mental Health Problems among Employees in Physically Demanding Jobs?

Research Paper Title

Physical working conditions and subsequent disability retirement due to any cause, mental disorders and musculoskeletal diseases: does the risk vary by common mental disorders?

Background

Physical work exposures and common mental disorders (CMD) have been linked to increased risk of work disability, but their joint associations with disability retirement due to any cause, mental disorders or musculoskeletal diseases have not been examined.

Methods

The data for exposures and covariates were from the Finnish Helsinki Health Study occupational cohort surveys in 2000-2002, 2007 and 2012.

The researchers used 12,458 observations from 6159 employees, who were 40-60 years old at baseline.

CMD were measured by the General Health Questionnaire (GHQ-12, cut-off point 3+).

Four self-reported work exposures (hazardous exposures, physical workload, computer and shift work) were combined with CMD and categorized as “neither”, “work exposure only”, “CMD only”, and “both”.

Associations with register-based disability retirement were assessed with Cox proportional hazards models for sample survey data adjusting for confounders over 5-year follow-up.

Additionally, synergy indices were calculated for the combined effects.

Results

Those reporting CMD and high physical workload had a greater risk of disability retirement due to any cause (HR 4.26, 95% CI 3.60-5.03), mental disorders (HR 5.41, 95% CI 3.87-7.56), and musculoskeletal diseases (HR 4.46, 95% CI 3.49-5.71) when compared to those with neither.

Synergy indices indicated that these associations were synergistic.

Similar associations were observed for CMD and hazardous exposures, but not for combined exposures to CMD and computer or shift work.

Conclusions

Identification of mental health problems among employees in physically demanding jobs is important to support work ability and reduce the risk of premature exit from work due to disability.

Reference

Halonen J.I., Mänty, M., Pietiläinen, O., Kujanpää, T., Kanerva, N., Lahti, J., Lahelma, E., Rahkonen, O. & Lallukka, T. (2020) Physical working conditions and subsequent disability retirement due to any cause, mental disorders and musculoskeletal diseases: does the risk vary by common mental disorders? Social Psychiatry and Psychiatric Epidemiology. doi: 10.1007/s00127-019-01823-6. [Epub ahead of print].

Should Service Users be Involved in Co-Designing Surveys they will Use?

Research Paper Title

Validation of a Comprehensive Patient Experience Survey for Addiction and Mental Health that was Co-designed with Service Users.

Background

A rigorous survey development process was undertaken to design and test a novel, comprehensive patient experience measure that can be used across the full continuum of addiction and mental health programs.

Service users were involved in all aspects of the measure’s development, including the selection of items, pre-testing, naming of the scales, and interpretation of the results.

Methods

Survey data was collected from 1222 patients in treatment in a variety of service settings across Alberta, Canada (89% outpatients; 60% female).

Results

An exploratory factor analysis identified five subscales-patient-centred care, treatment effectiveness, staff behaviour, availability and coordination of care, and communication.

The subscales had high internal reliability (Cronbach’s alpha = 0.77 to 0.85) and test-retest reliability ranged from 0.53 to 0.82 across the five scales.

Conclusions

Scores on the new instrument were correlated with treatment outcomes.

The assessment of patient experience should be integrated into a continuous, sustainable quality improvement process to be truly effective.

Reference

Currie, S.R., Liu, P., Adamyk-Simpson, J. & Stanich, J. (2020) Validation of a Comprehensive Patient Experience Survey for Addiction and Mental Health that was Co-designed with Service Users. Community Mental Health Journal. 56(4), pp.735-743. doi: 10.1007/s10597-019-00534-1. Epub 2020 Jan 1.

Mental Stress Tasks & the Prefrontal Cortex

Research Paper Title

Relationship Between Cerebral Blood Oxygenation and Electrical Activity During Mental Stress Tasks: Simultaneous Measurements of NIRS and EEG.

Background

The incidence of stress-induced psychological and somatic diseases has been increasing rapidly, and it is important to clarify the neurophysiological mechanisms of stress response in order to establish effective stress management methods.

The researchers previously reported that the prefrontal cortex (PFC) plays an important role in stress response.

Methods

In the present study, the researchers employed near-infrared spectroscopy (NIRS) and electroencephalography (EEG) to investigate the characteristics of PFC activity during mental arithmetic tasks.

A two-channel NIRS device was used to measure haemoglobin (Hb) concentration changes in the bilateral PFC during a mental arithmetic task (2 min) in normal adults.

Simultaneously, EEG was used to also measure bilateral PFC activity during the same task.

They evaluated concentration changes of oxy-Hb induced by the task while analysing α wave changes using power spectrum analysis.

Results

It was observed that oxy-Hb in the bilateral PFC increased significantly during the task (p < 0.05), while α wave power in the PFC decreased significantly (p < 0.01).

Conclusions

The present results indicate that mental stress tasks caused the activation of the bilateral PFC.

Simultaneous measurements of NIRS and EEG are useful for evaluating the neurophysiological mechanism of stress responses in the brain.

Reference

Nagasawa, Y., Ishida, M., Komuro, Y., Ushioda, S., Hu, L. & Sakatani, K. (2020) Relationship Between Cerebral Blood Oxygenation and Electrical Activity During Mental Stress Tasks: Simultaneous Measurements of NIRS and EEG. Advances in Experimental Medicine and Biology. 1232:99-104. doi: 10.1007/978-3-030-34461-0_14.

Can We Model Essential Connections in Obsessive-Compulsive Disorder Patients using Functional MRI?

Research Paper Title

Modeling essential connections in obsessive-compulsive disorder patients using functional MRI.

Background

Obsessive-compulsive disorder (OCD) is a mental disease in which people experience uncontrollable and repetitive thoughts or behaviours.

Clinical diagnosis of OCD is achieved by using neuropsychological assessment metrics, which are often subjectively affected by psychologists and patients.

In this study, the researchers propose a classification model for OCD diagnosis using functional MR images.

Methods

Using functional connectivity (FC) matrices calculated from brain region of interest (ROI) pairs, a novel Riemann Kernel principal component analysis (PCA) model is employed for feature extraction, which preserves the topological information in the FC matrices.

Hierarchical features are then fed into an ensemble classifier based on the XGBoost algorithm.

Finally, decisive features extracted during classification are used to investigate the brain FC variations between patients with OCD and healthy controls.

Results

The proposed algorithm yielded a classification accuracy of 91.8%.

Additionally, the well-known cortico-striatal-thalamic-cortical (CSTC) circuit and cerebellum were found as highly related regions with OCD.

To further analyse the cerebellar-related function in OCD, the researchers demarcated cerebellum into three sub-regions according to their anatomical and functional property.

Using these three functional cerebellum regions as seeds for brain connectivity computation, statistical results showed that patients with OCD have decreased posterior cerebellar connections.

Conclusions

This study provides a new and efficient method to characterise patients with OCD using resting-state functional MRI.

The researchers also provide a new perspective to analyse disease-related features.

Despite of CSTC circuit, their model-driven feature analysis reported cerebellum as an OCD-related region.

This paper may provide novel insight to the understanding of genetic aetiology of OCD.

Reference

Xing, X., Jin, L., Li, Q., Yang, Q., Han, H., Xu, C., Wei, Z., Zhan, Y., Zhou, X.S., Xue, Z., Chu, X., Peng, Z. & Shi, F. (2020) Modeling essential connections in obsessive-compulsive disorder patients using functional MRI. Brain and Behavior. 10(2):e01499. doi: 10.1002/brb3.1499. Epub 2020 Jan 1.

Education & Training should Aim to improve the Recognition & Treatment of Postpartum OCD

Research Paper Title

Advances in the pharmacological management of obsessive-compulsive disorder in the postpartum period.

Background

Obsessive-compulsive disorder (OCD) is a psychiatric disorder characterised by obsessions and compulsions.

Obsessions are defined as intrusive, recurrent and distressing thoughts, images or impulses, whereas compulsions are defined as repetitive behaviours or mental acts.

While there is an associated distress, and indeed oftentimes, the individual’s awareness that these behaviours are excessive and unreasonable, the individual continues to be disabled by an inability to cease their compulsions.

The postpartum period may herald the onset of OCD or precipitate an exacerbation of the preexisting OCD symptoms.

Common OCD symptom clusters occur in the postpartum period, with specific challenges associated with motherhood and lactation.

Areas Covered

This brief review aims to review the extent and nature of publications evaluating pharmacological treatment of OCD in the postpartum period.

Expert Opinion

Education and training should aim to improve the recognition and treatment of postpartum OCD.

Due to the limited nature of studies, more research is required to assess the role of selective serotonin reuptake inhibitors in the postpartum period.

Reference

Brakoulias, V., Viswasam, K., Dwyer, A., Raine, K.H. & Starcevic, V. (2020) Advances in the pharmacological management of obsessive-compulsive disorder in the postpartum period. Expert Opinion on Pharmacotherapy. 21(2), pp.163-165. doi: 10.1080/14656566.2019.1700229. Epub 2020 Jan 1.

Are Pre-service Military-related & Mental Disorder Factors Associated with Leaving the UK Armed Forces?

Research Paper Title

Pre-service Military-related and Mental Disorder Factors Associated with Leaving the UK Armed Forces.

Background

The UK Armed Forces (UKAF) have a substantial manning deficit as more personnel leave than join.

This article identified pre-service, military, and mental health factors giving rise to leaving the UKAF and estimated the contributions to leaving of those factors which are potentially amenable to modification.

Methods

This study utilised data from a three-phase cohort study (2004-2006, 2007-2009 and 2014-2016), commencing while respondents were serving in the UKAF (n = 10,836; 6,046 (55.8%) had left service).

Associations between leaving the services and socio-demographics, military career and experiences, and mental health were determined using Cox regression.

Contribution to leaving was based on population attributable fractions (PAF) from Cox regression.

Analyses were stratified by rank due to the different career structures of Commissioned Officers and enlisted personnel.

Results

Leaving the UKAF was associated with joining when older, being a woman with a child/children, Army service, combat role, lower education level, and poor mental health.

Factors contributing a significant proportion of leaving among enlisted personnel were joining over the age of 17, history of externalising behaviour, being female, common mental disorders, and alcohol misuse.

Among Commissioned Officers only age at joining and sex contributed significant proportions to leaving.

Conclusions

The key factors for leaving are education and higher age at recruitment.

These are not amenable to intervention, for policy, equity, and legal reasons.

Heavy drinking and common mental disorder symptoms may be more amenable to modification and hence reduce rates of leaving the UKAF.

Women are more likely to leave due to childbearing.

Reference

Burdett, H., Stevelink, S.A.M., Jones, N., Hull, L., Wessely, S. & Rona, R. (2020) Pre-service Military-related and Mental Disorder Factors Associated with Leaving the UK Armed Forces. Psychiatry. 1-16. doi: 10.1080/00332747.2020.1729063. [Epub ahead of print].

Are E-Mental Health Applications for Depression Beneficial?

Research Paper Title

E-mental health applications for depression: an evidence-based ethical analysis.

Background

E-mental health applications (apps) are an increasingly important factor for the treatment of depression.

To assess the risks and benefits for patients, an in-depth ethical analysis is necessary.

The objective of this paper is to determine the ethical implications of app-based treatment for depression.

Methods

An evidence-based ethical analysis was conducted.

The material was meta-reviews and randomised control studies (RCTs) on app-based treatment.

Based on the empirical data, an ethical analysis was conducted using the 3-ACES-approach by Thornicroft and Tansella.

Results

Apps may empower autonomy, offer an uninterrupted series of contacts over a period of time, show evidence-based benefits for patients with subclinical and mild-to-moderate-symptoms, are easily accessible, may be used for coordinating information and services within an episode of care, and are on the whole cost-effective.

Their risks are that they are not suitable for the whole range of severity of mental illnesses and patient characteristics, show severe deficits in the data privacy policy, and a big variability in quality standards.

Conclusions

The use of apps in depression treatment can be beneficial for patients as long as:

  • The usefulness of an app-based treatment is assessed for each individual patient;
  • Apps are chosen according to symptom severity as well as characteristics like the patient’s level of self-reliance, their e-literacy, and their openness vis-à-vis apps; and
  • Manufacturers improve their privacy policies and the quality of apps.

Reference

Rubeis, G. (2020) E-mental health applications for depression: an evidence-based ethical analysis. European Archives of Psychiatry and Clinical Neuroscience. doi: 10.1007/s00406-019-01093-y. [Epub ahead of print].

Can We Link Financial Worries & Poor Mental Health?

Research Paper Title

Sociodemographic Characteristics, Financial Worries and Serious Psychological Distress in U.S. Adults.

Background

Economic recessions have been well studied in relationship to poor mental health.

However, subjective financial worries have not been examined relative to serious psychological distress (SPD), a measure of poor mental health.

Methods

Adults 18 to 64 years in the cross-sectional 2016 National Health Interview Survey (n = 24,126) were examined for worries about paying for bills, serious medical events, expected medical costs, retirement, children’s college tuition and maintaining a standard of living; by sociodemographic such as sex and race/ethnicity. Over 50% of adults reported two or more financial worries.

Results

In multivariate models, financial worries were associated with SPD.

White adults at the lowest education level had the greatest proportion with SPD compared with all other race/ethnic groups.

Conclusions

Women had greater risk for SPD and for each financial worry compared with men.

Financial worries were prevalent in US adults, were associated with increased risk for SPD, and varied by sex.

Reference

Weissman, J., Russell, D. & Mann, J.J. (2020) Sociodemographic Characteristics, Financial Worries and Serious Psychological Distress in U.S. Adults. Community Mental Health Journal. 56(4), pp.606-613. doi: 10.1007/s10597-019-00519-0. Epub 2020 Jan 1.