Utility of Add-on Mirtazapine to Clozapine-Responsive Early-Onset Schizophrenia

Research Paper Title

Add-on mirtazapine to clozapine-responsive early-onset schizophrenia.

Abstract

Early-onset schizophrenia is notorious for poor prognostication and treatment-refractoriness.

Clozapine remains a viable option, albeit off-label, but is clearly underutilised in this population.

Use is typically fraught with panoply of drastic side effects.

Here, the authors report on an adolescent case with schizophrenia that responded ultimately to clozapine.

Add-on mirtazapine was advantageous spanning negative and cognitive symptom domains whilst addressing clozapine-related sialorrhea and urinary incontinence.

This might open new venues for such complicated clinical scenarios.

Reference

Moodliar, S., Naguy, A. & Elsori, D.H. (2019) Add-on mirtazapine to clozapine-responsive early-onset schizophrenia. Psychiatry Research. https://doi.org/10.1016/j.psychres.2019.112701.

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