What is Flourishing?

Introduction

Flourishing, or human flourishing, is the complete goodness of humans in a developmental life-span, that somehow includes positive psychological functioning and positive social functioning, along with other basic goods.

The term has gained more usage and interest in recent times, but is rooted in ancient philosophical and theological usages. Aristotle’s term eudaimonia is one source for understanding human flourishing. The Hebrew Scriptures, or the Old Testament, also speak of flourishing, as they compare the just person to a growing tree. Christian Scriptures, or the New Testament, build upon Jewish usage and speak of flourishing as it can exist in heaven. The medieval theologian Thomas Aquinas drew from Aristotle as well as the Bible, and utilised the notion of flourishing in his philosophical theology. More recently, the Positive Psychology of Martin Seligman, Corey Keyes, Barbara Fredrickson, and others, have expanded and developed the notion of human flourishing.

Empirical studies, such as those of the Harvard Human Flourishing Program, and practical applications, indicate the importance of the concept and the increasingly widespread use of the term in business, economics, and politics. In positive psychology, flourishing is “when people experience positive emotions, positive psychological functioning and positive social functioning, most of the time,” living “within an optimal range of human functioning.” It is a descriptor and measure of positive mental health and overall life well-being, and includes multiple components and concepts, such as cultivating strengths, subjective well-being, “goodness, generativity, growth, and resilience.” In this view, flourishing is the opposite of both pathology and languishing, which are described as living a life that feels hollow and empty.

Etymology and Definition

Although “flourishing” could refer to the general healthy state of a plant as it grows, properly speaking it is the stage in a vascular plant’s morphogenesis, specifically the stage of growth when it develops flowers.

Etymology

The English term “flourish” comes from the Latin florere, “to bloom, blossom, flower,” from the Latin flos, “a flower.” To contrast the term with a plant’s lack of full development, “flourish” came to indicate growth or development with vigour. Around 1597, the term came to include the notion of prosperity, insofar as a to bear flowers is an indication of the fullness of life and productivity.

Definitions

As an obvious consequence of the widespread use of the term “flourishing” in different fields and by different authors, there is not a general consensus about a definition of flourishing.

For instance, there is also a lot of debate about the mutual relations between flourishing and some related concepts, as the Aristotelian concept of eudaimonia, and the concepts of happiness and well-being. According to a Neo-Aristotelian view, the concept of human flourishing offers an explanation of the human good that is objective, inclusive, individualized, agent-relative, self-directed and social. It views human flourishing objectively because it is desirable and appealing. Flourishing is a state of being rather than a feeling or experience. It comes from engaging in activities that both express and produce the actualization of one’s potential.

According to some voices in Positive Psychology, flourishing is a “descriptor of positive mental health.” According to Fredrickson and Losada, flourishing is living:”

…within an optimal range of human functioning, one that connotes goodness, generativity, growth, and resilience.”

According to the Mental Health Foundation of New Zealand (Fredrickson & Lahoda, 2005), flourishing:”

…is a state where people experience positive emotions, positive psychological functioning and positive social functioning, most of the time. In more philosophical terms this means access to the pleasant life, the engaged or good life and the meaningful life […] It requires the development of attributes and social and personal levels that exhibit character strengths and virtues that are commonly agreed across different cultures (Seligman, Steen, Park and Peterson, 2005). On the other hand languishing includes states of experience where people describe their lives as “hollow” or “empty”.

According to Keyes, mental health does not imply an absence of mental illness. Rather, mental health is a “separate dimension of positive feelings and functioning.” Individuals described as flourishing have a combination of high levels of emotional well-being, psychological well-being, and social well-being. Flourishing people are happy and satisfied; they tend to see their lives as having a purpose; they feel some degree of mastery and accept all parts of themselves; they have a sense of personal growth in the sense that they are always growing, evolving, and changing; finally, they have a sense of autonomy and an internal locus of control, they chose their fate in life instead of being victims of fate.

Psychologist Martin Seligman, one of the founding fathers of happiness research, wrote in his book, Flourish, a new model for happiness and well-being based on positive psychology. This book expounds on simple exercises that anyone can do to create a happier life and to flourish. Flourish, is a tool to understand happiness by emphasizing how the five pillars of Positive Psychology, also known as PERMA, increase the quality of life for people who apply it to their lives.

According to Fredrickson and Losada (2005), flourishing is characterised by four main components: goodness, generative, growth, and resilience.

According to Keyes, only 18.1% of Americans are actually flourishing. The majority of Americans can be classified as mentally unhealthy (depressed) or not mentally healthy or flourishing (moderately mentally healthy/languishing).

Tyler J. VanderWeele, a prominent epidemiologist and expert in biostatistics who has extensively studied human flourishing, has proposed the following, quite different, definition:

Flourishing itself might be understood as a state in which all aspects of a person’s life are good. We might also refer to such a state as complete human well-being, which is again arguably a broader concept than psychological well-being. Conceptions of what constitutes flourishing will be numerous and views on the concept will differ. However, I would argue that, regardless of the particulars of different understandings, most would concur that flourishing, however conceived, would, at the very least, require doing or being well in the following five broad domains of human life: (i) happiness and life satisfaction; (ii) health, both mental and physical; (iii) meaning and purpose; (iv) character and virtue; and (v) close social relationships. All are arguably at least a part of what we mean by flourishing. […]If, however, we think about flourishing not only as a momentary state but also as something that is sustained over time, then one might also argue that a state of flourishing should be such that resources, financial and otherwise, are sufficiently stable so that what is going well in each of these five domains is likely to continue into the future for some time to come.[…] I would in no way claim that these domains above entirely characterize flourishing. […] I would only argue here that, whatever else flourishing might consist in, these five domains above would also be included, and thus these five domains above may provide some common ground for discussion.

Summary

To summarise the definitions above: Human flourishing is the ongoing fulfilment of human capacities within given contexts by advancing one’s own good and the common good.

In order to better understand this synthesis, one has to keep in mind that, in the view of Aristotle and Thomas Aquinas, a capacity of a being is a potential stemming from its nature to perform certain kinds of activities, or to undergo certain kinds of changes in accordance with its inner dynamism. For instance, the capacity to bear fruit or the capacity to grow are within a tree’s natural potential. On the other hand, the common good is some good—whether material or non-material—that has four characteristics: it is specific, in the sense that it is not general good-in-itself; it is objective, that is, it exists outside of the individual and is independent from the existence of any particular person; it is collective, for it exists only within some community; it is shareable, that is, many people can participate, enjoy, or use it simultaneously.

Aristotle and Flourishing

Aristotle and Biology

The Greek philosopher, Aristotle, contributed greatly to a deeper understanding of flourishing as a model for human life. Better-known for his work in metaphysics and logic, he was nevertheless a biologist first and foremost. His understanding of the development of flora and fauna, seen especially in his work Generation of Animals, provided a scientific background for recognising a similar development in the human being.

Eudaimonia

Aristotle’s term for the optimal state of the human being is eudaimonia (Greek: εὐδαίμονία). He gives various definitions and descriptions of eudaimonia, in the Nicomachean Ethics, the Eudemian Ethics, and in his Politics, among which:

  • “The active exercise of his soul’s faculties in conformity with excellence or virtue, or if there be several human excellences or virtues, in conformity with the best and most perfect among them. Moreover this activity must occupy a complete lifetime; for one swallow does not make spring, nor does one fine day; and similarly one day or a brief period of happiness does not make a man supremely blessed and happy.”
  • “Happiness therefore is co-extensive in its range with contemplation: the more a class of beings possesses the faculty of contemplation, the more it enjoys happiness, not as an accidental concomitant of contemplation but as inherent in it, since contemplation is valuable in itself. It follows that happiness is some form of contemplation.”
  • “So, as the function of the soul and of its excellence must be one and the same, the function of its excellence is a good life. This, then, is the final good, that we agreed to be happiness. It is evident from our assumptions (happiness was assumed to be the best thing, and ends-the best among goods-are in the soul; but things in the soul are states or activities), since the activity is better than the disposition, and the best activity is of the best state, and virtue is the best state, that the activity of the virtue of the soul must be the best thing. But happiness too was said to be the best thing: so happiness is the activity of a good soul. Now as happiness was agreed to be something complete, and life may be complete or incomplete-and this holds with excellence also (in the one case it is total, in the other partial)-and the activity of what is incomplete is itself incomplete, happiness must be activity of a complete life in accordance with complete virtue.”
  • “Happiness is the complete activity and employment of virtue, and this not conditionally but absolutely. When I say ‘conditionally’ I refer to things necessary, by ‘absolutely’ I mean ‘nobly: for instance, to take the case of just actions, just acts of vengeance and of punishment spring it is true from virtue, but are necessary, and have the quality of nobility only in a limited manner (since it would be preferable that neither individual nor state should have any need of such things), whereas actions aiming at honours and resources are the noblest actions absolutely; for the former class of acts consist in the removal of something evil, but actions of the latter kind are the opposite – they are the foundation and the generation of things good.”

Sometimes eudaimonia is translated as “happiness”; other times, as “welfare” or “well-being,” showing that no translation is fully adequate to capture its meaning in Greek.

Philosopher Joe Sachs emphasizes the importance of the activity of eudaimonia, a “being-at-work” of the human soul. This indicates that “flourishing” can adequately translate eudaimonia, insofar as the term signifies the dynamism of the principle of life and growth within a human.

Positive Psychology and Flourishing

Brief History

“Flourishing” as a psychological concept has been developed by Corey Keyes and Barbara Fredrickson.

Keyes collaborated with Carol Ryff in testing her Six-factor Model of Psychological Well-being, and in 2002 published his theoretical considerations in an article on The Mental Health Continuum: From Languishing to Flourishing. qualified by Fredrickson as “path-breaking work that measures mental health in positive terms rather than by the absence of mental illness.”

Barbara Fredrickson developed the broaden-and-build theory of positive emotions. According to Fredrickson there is a wide variety of positive effects that positive emotions and experiences have on human lives. Fredrickson notes two characteristics of positive emotions that differ from negative emotions:

  1. Positive emotions do not seem to elicit specific action tendencies the same way that negative emotions do. Instead, they seem to cause some general, non-direction oriented activation.
  2. Positive emotions do not necessarily facilitate physical action, but do spark significant cognitive action. For this reason, Fredrickson conceptualises two new concepts: thought-action tendencies, or what a person normally does in a particular situation, and thought-action repertoires, rather an inventory of skills of what a person is able to do.

Previous theories of emotion stated that all emotions are associated with urges to act in particular ways, called action-tendencies. According to Fredrickson, most positive emotions do not follow this model of action-tendencies, since they do not usually occur in life-threatening circumstances and thus do not generally elicit specific urges. Fredrickson proposes that instead of one general theory of emotions, psychologists should develop theories for each emotion or for subsets of emotions.

The broaden-and-build theory of positive emotions proposed by Fredrickson states that while negative emotions narrow thought-action tendencies to time tested strategies as handed down by evolution, positive emotions broaden thought-action repertoires. Positive emotions often cause people to discard time-tested or automatic action tendencies and pursue novel, creative, and often unscripted courses of thought and action. These positive emotions and thought-action repertoires can be seen as applicable to the concept of flourishing because flourishing children and adults have a much wider array of cognitive, physical, and social possibilities, which results in the empirical and actual successes of a flourishing life.

The concept has also been used by Martin E.P. Seligman, the founder of positive psychology, in his 2011 publication Flourish. Seligman, usually considered the father of positive psychology, characterizes human flourishing as excellence in 5 fields: positive emotion, engagement, relationships, meaning, and achievement. Consequently, his model of human flourishing is usually called the PERMA model. He claims also that health is an essential element of flourishing, but he presents a quite vast notion of health, including biological assets (e.g. the hormone oxytocin, longer DNA telomeres), subjective assets (e.g. optimism, vitality), and functional assets (good marriage, rich friendships, engaging work). Although Seligman’s PERMA model is certainly useful for psychological studies on flourishing, it doesn’t capture the essence of human flourishing, since it may allow us to consider as flourishing evidently evil people, as brutal dictators, if they test good in these five fields. To avoid this misunderstanding of human flourishing, Seligman himself, and also other thinkers as Christopher Peterson, have also discussed what they call “character strengths” or “virtues.”. Seligman gives the following definition of flourishing:

To flourish is to find fulfilment in our lives, accomplishing meaningful and worthwhile tasks, and connecting with others at a deeper level—in essence, living the “good life”.

Measurement and Diagnostic Criteria

With the concept of flourishing, psychologists can study and measure fulfilment, purpose, meaning, and happiness. Flourishing can be measured through self-report measures. Individuals are asked to respond to structured scales measuring the presence of positive affect, absence of negative affect, and perceived satisfaction with life. Participants are specifically asked about their emotions and feelings because scientists theorize that flourishing is something that manifests itself internally rather than externally.

Keyes has operationalized symptoms of positive feelings and positive functioning in life by reviewing dimensions and scales of subjective well-being and, therefore, creating a definition of flourishing. To complete, or “operationalize”, the definition of what it means to be functioning optimally, or flourishing, diagnostic criteria have been developed for a flourishing life:

  1. Individual must have had no episodes of major depression in the past year
  2. Individual must possess a high level of well-being as indicated by the individuals meeting all three of the following criteria
    • High emotional well-being, defined by 2 of 3 scale scores on appropriate measures falling in the upper tertile.
      • Positive affect
      • Negative affect (low)
      • Life satisfaction
    • High psychological well-being, defined by 4 of 6 scale scores on appropriate measures falling in the upper tertile.
      • Self-acceptance
      • Personal growth
      • Purpose in life
      • Environmental mastery
      • Autonomy
      • Positive relations with others
    • High social well-being, defined by 3 of 5 scale scores on appropriate measures falling in the upper tertile.
      • Social acceptance
      • Social actualisation
      • Social contribution
      • Social coherence
      • Social integration

Major Empirical Findings

Positive emotional feelings such as moods, and sentiments such as happiness, carry more personal and psychological benefits than just a pleasant, personal subjective experience. Flourishing widens attention, broaden behavioural repertoires, which means to broaden one’s skills or regularly performed actions, increase intuition, and increase creativity. Secondly, good feelings can have physiological manifestations, such as significant and positive cardiovascular effects, such as a reduction in blood pressure. Third, good feelings predict healthy mental and physical outcomes. Also, positive affect and flourishing is related to longevity. In a 2022 study of intrusive thoughts and flourishing, Jesse Omoregie and Jerome Carson found that people who experience flourishing would usually experience minimal intrusive thoughts. Omoregie and Carson further concluded that flourishing is a variable that helps in the reduction of psychological problems such as anxiety, depression, and intrusive thoughts.

The many components of flourishing elicit more tangible outcomes than simply mental or physiological results. For example, components such as self-efficacy, likability, and prosocial behaviour encourage active involvement with goal pursuits and with the environment. This promotes people to pursue and approach new and different situations. Therefore, flourishing adults have higher levels of motivation to work actively to pursue new goals and are in possession of more past skills and resources. This helps people to satisfy life and societal goals, such as creating opportunities, performing well in the workplace, and producing goods, work and careers that are highly valued in American society. Authors, Robert Kegan and Lisa Laskow Lahey, in their book, An Everyone Culture, “argues that organizations do best when they build an environment that encourages constant personal development among their employees.” This success results in higher satisfaction and reinforces Frederickson’s Broaden and Build model, for more positive adults reap more benefits and, are more positive, which creates an upward spiral.

Studies have shown that people who are flourishing are more likely to graduate from college, secure “better” jobs, and are more likely to succeed in that job. One reason for this success can be seen in the evidence offered above when discussing languishing: those that flourish have less work absenteeism, cited by Lyubomirsky as “job withdrawal.” Finally, those that are flourishing have more support and assistance from co-workers and supervisors in their workplace.

Flourishing has been found to impact more areas than simply the workplace. In particular community involvement and social relationships have been cited as something that flourishing influences directly. For example, those that flourish have been found to volunteer at higher levels across cultures. Moreover, in terms of social support and relationships, studies have shown that there is an association between flourishing and actual number of friends, overall social support, and perceived companionship.

Applications

The definition or conceptualisation of mental health under the framework of flourishing and languishing describes symptoms that can cooperate with intervention techniques aimed at increasing levels of emotional, social, and psychological well-being. Furthermore, as Keyes implies, in a world full of flourishing people, all would be able to reap the benefits that this positive mental state and life condition offers.

Education

Keyes mentions children as well as adults. He says that children are directly affected by maternal depression, and points out that the flourishing or languishing of teachers and the effect on students have not been studied. Keyes also speculates that teacher retention may be associated with the students’ frames of mind. Furthermore, if students can be made to flourish, the benefits to the education process are greater, as flourishing can increase attention and thought-action repertoires.

Engagement

Flourishing also has many applications to civic duty and social engagement. Keyes believes that most people do not focus enough on those aspects of life and focus instead on personal achievement. Keyes suggests that people should provide encouragement to children, and adults, to participate socially. People that exhibit flourishing are engaged in social participation and people that are engaged in social participation exhibit flourishing. Therefore, he suggests that people should give their kids a purpose, which creates a sense of contribution and environmental mastery that enhances feelings of well-being and fulfilment.

Criticisms

This psychological concept of flourishing is built on Fredrickson’s broaden-and-build theory of positive emotions, but some researchers have suggested that there are other functions of positive emotions. Mackie and Worth propose that positive emotions diminish cognitive capabilities. They showed that when exposed to a persuasive message for a limited amount of time, subjects experiencing a positive mood showed reduced processing as compared with subjects in a neutral mood. Others have suggested that positive emotions diminish the motivation but not the capacity for cognitive processing. Flourishing is still a newly developing subject of study and, more tests need to be done to fully define, operationalise, and apply the concept of flourishing; this lack of research is also one criticism of the concept of flourishing.

Contemporary Flourishing Research

Global Flourishing Study

It is a longitudinal study about human flourishing, involving data collection of individuals of 22 countries all around the world. It is carried out by scholars at the Human Flourishing Program at Harvard and Baylor’s Institute for Studies of Religion, in partnership with Gallup and the Centre for Open Science. Its preparation began in 2018 and its first data are expected by the summer of 2023.

Johns Hopkins: Paul McHugh Programme for Human Flourishing

This programme based at Johns Hopkins University, founded in 2015, and directed by Margaret S. Chisolm, aims at bringing the results of interdisciplinary research on health and human flourishing to an audience of both clinicians and clinicians-in-training.

Harvard Human Flourishing Programme

This programme was founded in 2016 at Harvard’s Institute for Quantitative Social Science and directed by Tyler J. VanderWeele. Its aim is to study and promote human flourishing.

University of Pennsylvania: Positive Psychology Centre and Flourishing and Humanities Project

This interdisciplinary research project, based at the University of Pennsylvania’s Positive Psychology Centre, directed by James Pawelski and founded in 2014, studies the relations of the arts and humanities with human flourishing.

Humanity 2.0

The Humanity 2.0 Foundation mission is to identify impediments to human flourishing and then work collaboratively across sectors to remove them by sourcing and scaling bold and innovative solutions. To support this mission, the Humanity 2.0 Institute integrates global research on key questions: What is human flourishing? What are the pathways to achieve human flourishing? What obstacles block these pathways? What are practical solutions to remove these obstacles? Research partners include the Human Flourishing Programme at Harvard University, the Pontifical Gregorian University and the University of Pennsylvania Positive Psychology Centre and Flourishing Humanities Project.

This page is based on the copyrighted Wikipedia article < https://en.wikipedia.org/wiki/Flourishing >; it is used under the Creative Commons Attribution-ShareAlike 3.0 Unported License (CC-BY-SA). You may redistribute it, verbatim or modified, providing that you comply with the terms of the CC-BY-SA.

What are Drug Addiction Recovery Groups?

Introduction

Drug addiction recovery groups are voluntary associations of people who share a common desire to overcome their drug addiction.

Outline

Different groups use different methods, ranging from completely secular to explicitly spiritual. Some programmes may advocate a reduction in the use of drugs rather than outright abstention. One survey of members who found active involvement in any addiction recovery group correlates with higher chances of maintaining sobriety. Although there is not a difference in whether group or individual therapy is better for the patient, studies show that any therapy increases positive outcomes for patients with substance use disorder. The survey found group participation increased when the individual members’ beliefs matched those of their primary support group (many addicts are members of multiple addiction recovery groups). Analysis of the survey results found a significant positive correlation between the religiosity of members and their participation in twelve-step programs (these programs describe themselves as spiritual rather than religious) and to a lesser level in non-religious SMART Recovery groups, the correlation factor being three times smaller for SMART Recovery than for the twelve-step addiction recovery groups. Religiosity was inversely related to participation in Secular Organisations for Sobriety.

A survey of a cross-sectional sample of clinicians working in outpatient facilities (selected from the SAMHSA On-line Treatment Facility Locator) found that clinicians only referring clients to twelve-step groups were more likely than those referring their clients to twelve-step groups and “twelve-step alternatives” to believe less strongly in the effectiveness of Cognitive Behavioural and psychodynamic-oriented therapy, and were likely to be unfamiliar with twelve-step alternatives. A logistic regression of clinician’s knowledge and awareness of Cognitive Behavioural Therapy effectiveness and preference for the twelve-step model was correlated with referring exclusively to twelve-step groups.

Twelve-Step Recovery Groups

Twelve-step programs are mutual aid organizations for the purpose of recovery from substance addictions, behavioural addictions and compulsions. Developed in the 1930s by alcoholics, the first twelve-step programme, Alcoholics Anonymous (AA), aided its membership to overcome alcoholism. Since that time, dozens of other organisations have been derived from AA’s approach to address problems as varied as drug addiction, compulsive gambling, sex and overeating. All twelve-step programmes utilise a version of AA’s suggested twelve steps first published in the 1939 book Alcoholics Anonymous: The Story of How More Than One Hundred Men Have Recovered from Alcoholism.

As summarised by the American Psychological Association (APA), the process involves the following:

  • Admitting that one cannot control one’s alcoholism, addiction, or compulsion;
  • Coming to believe in a Higher Power that can give strength;
  • Examining past errors with the help of a sponsor (experienced member);
  • Making amends for these errors;
  • Learning to live a new life with a new code of behaviour; and
  • Helping others who suffer from the same alcoholism, addictions, or compulsions.

Participants attend meetings and are able to make new connections with other members who are striving towards a similar goal. If a person is unable to attend a meeting face-to-face, many of the groups have meetings by phone or online as another option. Each group has its own textbook, workbooks or both, which provide information about their program of recovery and suggestions on how to “work the steps”. Often, free literature is available for anyone who asks for it at a meeting. This provides potential new members or family members with relevant information about both the addiction and that specific groups’ version of the twelve-step process of recovery. New members are invited to work with another member who has already been through the twelve-steps at least once. That person serves as a guide to the new member, answers questions and provides feedback as the new member goes through the steps. These groups are spiritually based and encourage a belief in a power greater than the members. Most do not have one specific conception of what that means and allow the member to decide what spirituality means to them as it applies to their recovery. The groups emphasize living on a spiritual yet not necessarily religious basis. Groups typically advocate for complete abstinence, usually from all drugs including alcohol. This is because of the perceived potential for cross-addiction, the idea that there is a tendency to trade one addiction for another. Despite the idea of cross-addiction being accepted as real in many addiction recovery groups, there is said to be little empirical evidence to support it and recent research suggests that the opposite is more likely to be true.

The following is a list of twelve-step drug addiction recovery groups. Twelve-step programmes for problems other than drug addiction also exist.

  • Alcoholics Anonymous (AA) – This group gave birth to the twelve-step programme of recovery. Meetings are focused on alcoholism only and advocate complete abstinence. Meetings are held all over the world.
  • Cocaine Anonymous (CA) – This group is focused on cessation of cocaine and all other mind-altering substances. The programme advocates complete abstinence from all mind-altering substances in order to recover from the disease of addiction. Meetings are held all over the world.
  • Celebrate Recovery (CR) – Celebrate recovery is a recovery programme for any life problem, including addiction to alcohol and other drugs. In contrast to most 12-step programmes, the group recognises Jesus Christ as their higher power. Their groups are located in the United States.
  • Crystal Meth Anonymous (CMA) – This group focuses on abstinence from crystal meth although it does recognise the potential for cross-addiction, the tendency for an addict to substitute one addiction for another. Meetings are currently available in eight countries.
  • Heroin Anonymous (HA) – This group is focused on abstinence from heroin along with all other drugs including alcohol. Meetings are held in England and the United States.
  • Marijuana Anonymous (MA) – This group focuses of recovery from marijuana addiction. Groups meet in eleven countries.
  • Nicotine Anonymous (NicA) – This group is for those desiring to stop the use of nicotine in all forms. Groups are available in many countries.
  • Narcotics Anonymous (NA) – This group has meetings in 139 countries and focuses on recovery from the use of all drugs and alcohol. The group makes no distinction between any mood or mind-altering substance and encourages members to look for similarities the common problem they all share, rather than focusing on the differences.
  • Pagans in Recovery (PIR) – Pagans in recovery have adapted the twelve-step programme of recovery into language that is not overtly Christian as it was originally written so that those with other belief systems can more comfortably work the programme. They have their own literature but do not currently have an official site for meeting availability.
  • Pills Anonymous (PA) – This group is focused on addiction to pills and all other mind-altering substances. Groups are available in seven countries.

Non-Twelve-Step Recovery Groups

These groups do not follow the twelve-step recovery method, although their members may also attend twelve-step meetings. It is common for individuals to try many different meetings and groups while in recovery. What works for one may not work for another, so trying different types of meetings can be helpful to someone seeking recovery from drugs and alcohol.

  • The Washingtonians – A defunct 19th Century mutual aid society founded by alcoholics with a desire to maintain sobriety
  • Association of Recovering Motorcyclists (ARM) – This association of recovering motorcyclists is a brotherhood of men recovering from alcohol and/or drug addiction. They support one another in remaining abstinent from drugs and alcohol while continuing to ride motorcycles together regularly.
  • Recovering Women Riders (RWR) – Recovering women riders is a sisterhood of recovering women motorcyclists. Affiliated with the association of recovering motorcyclists, they also seek to support one another in remaining abstinent from drugs and alcohol while continuing to enjoy the lifestyle of riding bikes together.
  • LifeRing Secular Recovery (LSR)
  • Moderation Management (MM)
  • Rational Recovery (largely defunct)
  • Recovery Dharma (RD)
  • Refuge Recovery (RR)
  • Secular Organizations for Sobriety (SOS)
  • SMART Recovery
  • Women for Sobriety (WFS)

This page is based on the copyrighted Wikipedia article < https://en.wikipedia.org/wiki/Drug_addiction_recovery_groups >; it is used under the Creative Commons Attribution-ShareAlike 3.0 Unported License (CC-BY-SA). You may redistribute it, verbatim or modified, providing that you comply with the terms of the CC-BY-SA.

What is 8-OH-DPAT?

Introduction

8-OH-DPAT is a research chemical of the aminotetralin chemical class which was developed in the 1980s and has been widely used to study the function of the 5-HT1A receptor. It was one of the first major 5-HT1A receptor full agonists to be discovered.

Refer to Azapirone.

Originally believed to be selective for the 5-HT1A receptor, 8-OH-DPAT was later found to act as a 5-HT7 receptor agonist and serotonin reuptake inhibitor/releasing agent as well.

In animal studies, 8-OH-DPAT has been shown to possess antidepressant, anxiolytic, serenic, anorectic, antiemetic, hypothermic, hypotensive, bradycardic, hyperventilative, and analgesic effects.

This page is based on the copyrighted Wikipedia article < https://en.wikipedia.org/wiki/8-OH-DPAT >; it is used under the Creative Commons Attribution-ShareAlike 3.0 Unported License (CC-BY-SA). You may redistribute it, verbatim or modified, providing that you comply with the terms of the CC-BY-SA.

What is Tandospirone?

Introduction

Tandospirone, sold under the brand name Sediel, is an anxiolytic and antidepressant medication used in Japan and China, where it is marketed by Dainippon Sumitomo Pharma. It is a member of the azapirone class of drugs and is closely related to other azapirones like buspirone and gepirone.

Tandospirone was introduced for medical use in Japan in 1996 and in China in 2004.

Medical Uses

Anxiety and Depression

Tandospirone is most commonly used as a treatment for anxiety and depressive disorders, such as generalised anxiety disorder and dysthymia respectively. For both indications it usually takes a couple of weeks for therapeutic effects to begin to be seen, although at higher doses more rapid anxiolytic responses have been seen. It has also been used successfully as a treatment for bruxism.

Augmentation for Depression

Tandospirone can be used as an effective augmentation, especially when coupled with fluoxetine or clomipramine.

Other Uses

Tandospirone has been tried successfully as an adjunctive treatment for cognitive symptoms in schizophrenic individuals.

Side Effects

Common adverse effects include:

  • Dizziness
  • Drowsiness
  • Insomnia
  • Headache
  • Gastrointestinal disorders
  • Dry mouth
  • Negative influence on explicit memory function
  • Nausea

Adverse effects with unknown frequency include:

  • Hypotension (low blood pressure)
  • Dysphoria
  • Tachycardia
  • Malaise
  • Psychomotor impairment

It is not believed to be addictive but is known to produce mild withdrawal effects (e.g. anorexia) after abrupt discontinuation.

Pharmacology

Pharmacodynamics

Tandospirone acts as a potent and selective 5-HT1A receptor partial agonist, with a Ki affinity value of 27 ± 5 nM and approximately 55 to 85% intrinsic activity. It has relatively weak affinity for the 5-HT2A (1,300 ± 200), 5-HT2C (2,600 ± 60), α1-adrenergic (1,600 ± 80), α2-adrenergic (1,900 ± 400), D1 (41,000 ± 10,000), and D2 (1,700 ± 300) receptors, and is essentially inactive at the 5-HT1B, 5-HT1D, β-adrenergic, and muscarinic acetylcholine receptors, serotonin transporter, and benzodiazepine allosteric site of the GABAA receptor (all of which are > 100,000). There is evidence of tandospirone having low but significant antagonistic activity at the α2-adrenergic receptor through its active metabolite 1-(2-pyrimidinyl)piperazine (1-PP).

Society and Culture

Name

Tandospirone is also known as metanopirone and by the developmental code name SM-3997. It is marketed in Japan under the brand name Sediel.

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What is Perospirone?

Introduction

Perospirone (Lullan) is an atypical antipsychotic of the azapirone family. It was introduced in Japan by Dainippon Sumitomo Pharma in 2001 for the treatment of schizophrenia and acute cases of bipolar mania.

Medical Uses

Its primary uses are in the treatment of schizophrenia and bipolar mania.

Schizophrenia

In a clinical trial that compared it to haloperidol in the treatment of schizophrenia it was found to produce significantly superior overall symptom control. In another clinical trial perospirone was compared with mosapramine and produced a similar reduction in total PANSS score, except with respect to the blunted affect part of the PANSS negative score, in which perospirone produced a significantly greater improvement. In an open-label clinical trial comparing aripiprazole with perospirone there was no significant difference between the two treatments discovered in terms of both efficacy and tolerability. In 2009 a clinical trial found that perospirone produced a similar reduction of PANSS score than risperidone and the extrapyramidal side effects was similar in both frequency and severity between groups.

A meta-analysis published in 2013 found that it is statistically significantly less efficacious than other second-generation antipsychotics.

Adverse Effects

Has a higher incidence of extrapyramidal side effects than the other atypical antipsychotics, but still less than that seen with typical antipsychotics. A trend was observed in a clinical trial comparing mosapramine with perospirone that favoured perospirone for producing less prominent extrapyramidal side effects than mosapramine although statistical significant was not reached. It may produce less QT interval (measurement made on an electrocardiogram used to assess some of the electrical properties of the heart) prolongation than zotepine, as in one patient who had previously been on zotepine switching to perospirone corrected their prolonged QT interval. It also tended to produce less severe extrapyramidal side effects than haloperidol in a clinical trial comparing the two (although statistical significance was not reached).

Discontinuation

The British National Formulary recommends a gradual withdrawal when discontinuing antipsychotics to avoid acute withdrawal syndrome or rapid relapse. Symptoms of withdrawal commonly include nausea, vomiting, and loss of appetite. Other symptoms may include restlessness, increased sweating, and trouble sleeping. Less commonly there may be a felling of the world spinning, numbness, or muscle pains. Symptoms generally resolve after a short period of time.

There is tentative evidence that discontinuation of antipsychotics can result in psychosis. It may also result in reoccurrence of the condition that is being treated. Rarely tardive dyskinesia can occur when the medication is stopped.

Pharmacology

Perospirone binds to the following receptors with very high affinity (as an antagonist unless otherwise specified):

  • 5-HT1A (partial agonist; Ki=2.9 nM)
  • 5-HT2A (inverse agonist; Ki=1.3 nM)
  • D2 (Ki = 0.6 nM)

And the following receptor with high affinity:

  • H1 (inverse agonist)

And the following with moderate affinity:

  • D4
  • α1 adrenoceptor

And with low affinity for the following receptor:

  • D1

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What is Umespirone?

Introduction

Umespirone (KC-9172) is a drug of the azapirone class which possesses anxiolytic and antipsychotic properties.

Outline

It behaves as a 5-HT1A receptor partial agonist (Ki = 15 nM), D2 receptor partial agonist (Ki = 23 nM), and α1-adrenoceptor receptor antagonist (Ki = 14 nM), and also has weak affinity for the sigma receptor (Ki = 558 nM).

Unlike many other anxiolytics and antipsychotics, umespirone produces minimal sedation, cognitive/memory impairment, catalepsy, and extrapyramidal symptoms.

Synthesis

The condensation between ethyl cyanoacetate and acetone gives ethylisopropylidenecyanoacetate 759-58-0. This product is reacted with N-butylcyanoacetamide 39581-21-0 in sodium methoxide solution to give N-butyl-2,4-dicyano-3,3-dimethylglutarimide, CID:10681941. The glutarimide is cyclized with phosphoric acid to yield 3-butyl-9,9-dimethyl-3,7-diazabicyclo[3.3.1]nonane-2,4,6,8-tetraone, https://pubchem.ncbi.nlm.nih.gov/compound/10825633 CID:10825633.

The reaction between 1-(o-anisyl)piperazine 35386-24-4 and 1,4-dibromobutane 110-52-1 gives the Quat salt CID:15895413.

Convergent synthesis (in the presence of potassium carbonate) affords Umespirone (KC-9172).

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What is Tiospirone?

Introduction

Tiospirone (BMY-13,859), also sometimes called tiaspirone or tiosperone, is an atypical antipsychotic of the azapirone class.

Outline

It was investigated as a treatment for schizophrenia in the late 1980s and was found to have an effectiveness equivalent to those of typical antipsychotics in clinical trials but without causing extrapyramidal side effects.

However, development was halted and it was not marketed.

Perospirone, another azapirone derivative with antipsychotic properties, was synthesized and assayed several years after tiospirone.

It was found to be both more potent and more selective in comparison and was commercialised instead.

Pharmacology

Pharmacodynamics

Tiospirone acts as a 5-HT1A receptor partial agonist, 5-HT2A, 5-HT2C, and 5-HT7 receptor inverse agonist, and D2, D4, and α1-adrenergic receptor antagonist.

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What is Zalospirone?

Introduction

Zalospirone (WY-47,846) is a selective 5-HT1A partial agonist of the azapirone chemical class.

It was found to be effective in the treatment of anxiety and depression in clinical trials, but a high proportion of subjects dropped out due to side effects and development was subsequently never completed.

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What is Revospirone?

Introduction

Revospirone (Bay Vq 7813) is an azapirone drug which was patented as a veterinary tranquiliser but was never marketed.

It acts as a selective 5-HT1A receptor partial agonist.

Similarly to other azapirones such as buspirone, revospirone produces 1-(2-pyrimidinyl)piperazine (1-PP) as an active metabolite.

As a result, it also acts as an α2-adrenergic receptor antagonist to an extent.

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What is Ipsaprione?

Introduction

Ipsapirone is a selective 5-HT1A receptor partial agonist of the piperazine and azapirone chemical classes.

It has antidepressant and anxiolytic effects.

Ipsapirone was studied in several placebo-controlled trials for depression and continues to be used in research.

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