Introduction

Difludiazepam is a benzodiazepine derivative which is the 2′,6′-difluoro derivative of fludiazepam.

Background

It was invented in the 1970s but was never marketed, and has been used as a research tool to help determine the shape and function of the GABA_A receptors, at which it has an IC50 of 4.1nM.

Difludiazepam has subsequently been sold as a designer drug, and was first notified to the EMCDDA by Swedish authorities in 2017.