Tag: Difludiazepam

What is Fludiazepam?

Published on by Andrew Marshall1 Comment

Introduction

Fludiazepam, marketed under the brand name Erispan, is a potent benzodiazepine and 2สน-fluoro derivative of diazepam.

Refer to Difludiazepam.

Background

It was originally developed by Hoffman-La Roche in the 1960s.

It is marketed in Japan and Taiwan. It exerts its pharmacological properties via enhancement of GABAergic inhibition.

Fludiazepam has 4 times more binding affinity for benzodiazepine receptors than diazepam. It possesses anxiolytic, anticonvulsant, sedative, hypnotic and skeletal muscle relaxant properties. Fludiazepam has been used recreationally.

What is Difludiazepam?

Published on by Andrew Marshall1 Comment

Introduction

Difludiazepam is a benzodiazepine derivative which is the 2′,6′-difluoro derivative of fludiazepam.

Background

It was invented in the 1970s but was never marketed, and has been used as a research tool to help determine the shape and function of the GABAA receptors, at which it has an IC50 of 4.1nM.

Difludiazepam has subsequently been sold as a designer drug, and was first notified to the EMCDDA by Swedish authorities in 2017.