Pre-Clinical Dementia & Depression

Research Paper Title

A cross-national study of depression in preclinical dementia: A COSMIC collaboration study.


Depression commonly accompanies Alzheimer’s disease, but the nature of this association remains uncertain.


Longitudinal data from the COSMIC consortium were harmonized for eight population-based cohorts from four continents.

Incident dementia was diagnosed in 646 participants, with a median follow-up time of 5.6 years to diagnosis.

The association between years to dementia diagnosis and successive depressive states was assessed using a mixed effect logistic regression model.

A generic inverse variance method was used to group study results, construct forest plots, and generate heterogeneity statistics.


A common trajectory was observed showing an increase in the incidence of depression as the time to dementia diagnosis decreased despite cross-national variability in depression rates.


The results support the hypothesis that depression occurring in the preclinical phases of dementia is more likely to be attributable to dementia-related brain changes than environment or reverse causality.


Carles, S., Carriere, I., Reppermund, S., Davin, A., Guaita, A. et al. (2020) A cross-national study of depression in preclinical dementia: A COSMIC collaboration study. Alzheimer’s & Dementia. doi: 10.1002/alz.12149. Online ahead of print.

Book: Dementia: Support for Family and Friends

Book Title:

Dementia: Support for Family and Friends

Author(s): Dave Pulsford and Rachel Thompson.

Year: 2019.

Edition: Second (2nd).

Publisher: Jessica Kingsley Publishers.

Type(s): Paperback and Kindle.


A comprehensive and practical guide to dementia, this book is essential reading for anyone who has a friend or relative with the condition.

This updated edition reflects new guidance on approaches to supporting people with dementia, focussing especially on the UK, and includes quotes from people with dementia as well as from family carers.

The book explores each stage of the journey people with dementia face and explains how it affects the person, as well as those around them both at home and in residential settings.

It shows how best to offer support and where to get professional and informal assistance.

Focussing on the progressive nature of dementia and the issues that can arise as a result, it gives practical advice that can help to ensure the best possible quality of life both for the person with dementia and the people around them.