Do Brain “Globalopathies” Cause Mental Disorders?

Research Paper Title

Brain “Globalopathies” Cause Mental Disorders.

Background

“Consciousness” “mood,” “identity” and “personality” are all emergent properties from whole-brain organisations; these are typically disturbed in psychiatric disorders.

This work proposes that the underlying etiopathology of mental disorders originates from disturbances to global brain dynamics, or “Globalopathies” that are divided into three major interdependent types:

  1. “Resting-State Networkpathies,” in personality disorders;
  2. “Entropiathies” in mood disorders; and
  3. “Connectopathies” in psychosis and schizophrenia spectrum disorders.

Novel approaches of processing signals from the brain are beginning to reveal brain organization in health and disease. For example a “small world network” has been described for optimal brain functions and breakdown of that organisation might underlie relevant psychiatric manifestations.

A novel diagnostic reformulation can be generated based on pathologies of whole brain organisations, such new brain related diagnostic nosology is testable and thus can be validated.

Once validated Globalopathies can provide for “Global-therapies” i.e., interventions that can reorganise the brain and cure psychiatric disorders.

The technology for such interventions is becoming available.

Reference

Peled, A. (2020) Brain “Globalopathies” cause mental disorders. Medical Hypotheses. 81(6), pp.1046-1055. doi: 10.1016/j.mehy.2013.09.032. Epub 2013 Oct 5.

With Regard to Mental Health & Substance Use Disorders what is the Reality of Youth in Custody?

Research Paper Title

Mental health and substance use disorders: The reality of youth in custody.

Background

Young offenders experience a higher prevalence of mental health disorders and substance use disorders than the general population, estimated to be between 70% and 90% (Indig et al. 2011; Kenny et al., 2006; Lader et al., 2000; Teplin et al., 2002). In addition, comorbidities affect many young offenders, with over 60% presenting with two or more disorders (Justice Health & Forensic Mental Health Network and Juvenile Justice NSW, 2015). The prevalence of mental health disorders is higher among females, with young female offenders more likely to be diagnosed with anxiety and depressive disorders, as well as substance‐induced disorders (Justice Health & Forensic Mental Health Network and Juvenile Justice NSW, 2015).

Aboriginal and Torres Strait Islander youth are over‐represented within the juvenile justice system. In a report by the Australian Institute of Health and Welfare, it was found that 50% of young offenders in 2016-2017 identified as Aboriginal and/or Torres Strait Islander (Australian Institute of Health and Welfare 2018). Mental health and substance use disorders are the most common non‐communicable diseases among this group with 33% reporting high to very high levels of psychological distress (Azzopardi et al. 2018). Furthermore, there is evidence to suggest that poor family cohesion and the presence of adverse events in this group of adolescents are a reliable predictor of negative mental health outcomes (Young et al. 2016).

A recent Australian study reported the strongest predictor of incarceration and re‐incarceration was problematic alcohol and drug use (Indig et al., 2016). Indig et al. found that young people who were heavy drinkers were seven times more likely to have been previously incarcerated and three times more likely to be re‐incarcerated within 18 months. Indig et al. (2016) also found that illicit substance use was a consistent predictor of incarceration and re‐incarceration.

In addition to issues with drugs and alcohol, many incarcerated young people also report experiencing adverse childhood experiences during their childhood years with as many as 90% reporting at least one traumatic event (Ford et al., 2012). A recent Australian study found that 60% of young offenders reported a history of child abuse or neglect, 20% met the criteria for posttraumatic stress disorder (PTSD) (Moore et al. 2013). A history of adverse childhood experiences is the main predictor of a diagnosis of PTSD (Moore et al. 2013). Evidence suggests a link between exposure to adverse childhood experiences and the occurrence of various mental health difficulties among young offenders (McReynolds & Wasserman, 2011; Wasserman & McReynolds, 2011; Wilson et al., 2009).

It is unfortunate that many troubled youth are not recognized as being distressed or having mental health difficulties, and so do not have access to appropriate mental health care. Furthermore, these young people and their families may have very low levels of mental health literacy. However, once these young people come to the attention of the justice system, we have an opportunity to raise mental health literacy and provide appropriate services. There is a need for programmes and services that address mental health and substance use issues to assist young people improve their health outcomes and reduce their offending behaviours. Programmes such as monthly recovery management check‐ups in the first 90 days postrelease could help to achieve this outcome (Indig et al., 2016).

Given the high rate of adverse childhood experiences in incarcerated youth and the known link to PTSD, we need to ensure that services are informed by a trauma informed approach (Moore et al. 2013). There is also an identified need to invest in prevention and early intervention for young people. Currently, there are diversion programmes offered within the local court system in NSW for adult offenders exhibiting mental health (Statewide Community & Court Liaison Service) or substance use disorders (Magistrates Early Referral Into Treatment (MERIT)). However, these programmes are not available to offenders under the age of 18 years and adolescent diversion programmes are not routinely or diversely available to young people residing outside of the Sydney metropolitan area.

The mental health and substance use issues affecting young offenders challenge us to respond with effective interventions. Mental health nurses have an important role to play in improving the services and interventions available to these young people. Changes have been made to services for young offenders but more needs to be done. Research has shown that diversion and treatment services delivered in the community using a trauma informed approach are more effective in this population (Dierkhising et al. 2013). Moving forward, mental health nurses have an opportunity to take the lead in this important area.

Reference

Usher, K., Douglas, L. & Jackson, D. (2020) Mental health and substance use disorders: The reality of youth in custody. International Journal of Mental Health Nursing. 28(3). https://doi.org/10.1111/inm.12597.

The Current Debate on Whether Somatoform Disorders are Mental Disorders

Research Paper Title

Are somatoform disorders ‘mental disorders’? A contribution to the current debate.

Background

During the last 2 years, a debate has started over whether the somatoform symptoms/medically unexplained symptoms are wrongly placed under the category of mental disorders (section F in International classification of diseases-10 and in Diagnostic and statistical manual for mental disorders-IV).

Recent Findings

Most experts on medically unexplained symptoms agree that there is a substantial need for revision of the diagnoses of somatoform disorders. While some authors suggest moving the somatoform disorders from axis I to axis III, others suggest improving the classification of these syndromes on axis I, such as by using empirically derived criteria and by introducing psychological descriptors which justify the categorisation as a mental disorder.

In contrast to the situation when the last version of Diagnostic and statistical manual for mental disorders was published, new empirical data has shown some psychological and behavioural characteristics of patients with somatoform symptoms. These and other empirically founded approaches can be landmarks for the revision of this section in Diagnostic and statistical manual for mental disorders-V and International classification of diseases-11.

Summary

The classification of somatoform disorders as ‘mental disorders’ could be justified if empirically founded psychological and behavioural characteristics are included into the classification process.

Attention focusing, symptom catastrophising, and symptom expectation are outlined as possible examples of involved psychological processes.

Reference

Rief, W. & Isaac, M. (2020) Are somatoform disorders ‘mental disorders’? A contribution to the current debate. Current Opinion in Psychiatry. 20(2), pp.143-146. doi: 10.1097/YCO.0b013e3280346999.

Highlighting the Hidden Links between Mental Disorders

Research Paper Title

The hidden links between mental disorders.

Background

Psychiatrists have a dizzying array of diagnoses and not enough treatments. Hunting for the hidden biology underlying mental disorders could help.

In 2018, psychiatrist Oleguer Plana-Ripoll was wrestling with a puzzling fact about mental disorders. He knew that many individuals have multiple conditions – anxiety and depression, say, or schizophrenia and bipolar disorder. He wanted to know how common it was to have more than one diagnosis, so he got his hands on a database containing the medical details of around 5.9 million Danish citizens.

You can continue reading the full article here.

Reference

Marshall, M. (2020) The hidden links between mental disorders. Nature. 581(7806), pp.19-21. doi: 10.1038/d41586-020-00922-8.

Creativity & its Role in the Treatment & Recovery of those with Mental Disorders

Research Paper Title

Creativity, mental disorders and their treatment: recovery-oriented psychopharmacotherapy.

Background

This paper discusses interrelations between creativity, mental disorders and their treatment.

The psychology of creativity is very important for successful psychopharmacotherapy, but our knowledge about creativity is still insufficient.

Even that which is known is not within the armamentarium of most practicing psychiatrists.

  • In the first part of this article creativity and possible associations between creativity, mental health, and well-being are described.
  • The second part deals with the intriguing relationship between creativity and mental disorders.
  • The third part emphasizes the role of creativity in the treatment of mental disorders.

This paper ends by underlining the importance of a creativity-enhancing oriented, and personal recovery-focused psychopharmacotherapy in helping psychiatric patients achieve fulfilled and purposeful lives.

Reference

Jakovljevic, M. (2020) Creativity, mental disorders and their treatment: recovery-oriented psychopharmacotherapy. Psychiatria Danubina. 25(3), pp.311-315.

Linking Brain Imagery, Brain Tumours, and Cognitive & Mental Disorders in Adults

Research Paper Title

Brain tumours, cognitive and mental disorders in adults.

Background

Cognitive and mental disorders are observed in 15-20% of brain tumours, and can be the first symptoms.

The severity of cognitive deficits varies from attention and reasoning disorders to major syndromes such as delirium, amnesic syndrome or dementia.

Mental disorders range from apathy, irritability to major depressive or psychotic symptoms.

Cognitive and mental disorders are related to many factors including the localisation and nature of the tumour, peritumoral and remote changes, and personal susceptibility.

The diagnosis of brain tumour is presently made by brain imagery, but the difficulty remains to determine when imagery is to be used in cognitive or mental disorders.

Reference

Derouesne, C. (2020) Brain tumors, cognitive and mental disorders in adults. Geriatrie et Psychologie Neuropsychiatrie du Vieillissement. 13(2), pp.187-194. doi: 10.1684/pnv.2015.0533.

What are the Incidence Rates of Treated Mental Disorders in Childhood & Adolescence?

Research Paper Title

Incidence Rates of Treated Mental Disorders in Childhood and Adolescence in a Complete Nationwide Birth Cohort.

Background

To investigate incidences, cumulative incidence rates, and risk factors of diagnosed mental disorders in a complete nationwide birth cohort across the entire period of childhood and adolescence.

Methods

Based on nationwide Danish registries, the entire cohort of all children born in 1995 was followed up to 31 December 2013. Data for children who migrated during the period were censored in the time analyses, and death before age 18 years was considered a competing risk. Incidence rates and cumulative incidence rates for any first-time-diagnosed mental disorder and 10 major categories of mental disorders according to ICD-10 criteria were calculated for 68,982 individuals. In addition, the effects of age, sex, and further child- and family-related risk factors on mental disorders were analysed.

Results

The incidences of any mental disorder, substance use disorders, depression, and anxiety disorders showed an increase in adolescence, whereas those for autism spectrum disorders, attention-deficit/hyperactivity disorder, conduct disorder, and tic disorder increased during childhood and decreased thereafter. Males had higher incidence rates of any mental disorders, substance use disorders, autism spectrum disorders, ADHD, conduct disorder, and tic disorder. Females had higher risks for depressive, anxiety, obsessive-compulsive, and eating disorders. Several other risk and protective factors for any mental disorder were identified. The cumulative incidence rate at age 18 years amounted to 11.02% for any mental disorder.

Conclusions

These findings provide the most comprehensive estimates of the development, incidence rates, and contributing risk factors of registered mental disorders for the entire period of childhood and adolescence that have been calculated so far.

Reference

Steinhausen, H-C. & Jakobsen, H. (2020) Incidence Rates of Treated Mental Disorders in Childhood and Adolescence in a Complete Nationwide Birth Cohort. The Journal of Clinical Psychiatry. 80(3):17m12012. doi: 10.4088/JCP.17m12012.

Older People: Physical Health, Check; Mental Health, Overlooked

Research Paper Title

Promoting active ageing in older people with mental disorders living in the community: An integrative review.

Background

Approximately 15% of older people aged 60 and above are experiencing a mental disorder. However, they are commonly unrecognised from health care providers.

Therefore the purpose of this research was to critically synthesise the evidence in relation to the promotion of active ageing in older people, including those with mental disorders.

Methods

This study is an integrative review. Articles published between January 2002 and March 2017 in English and in Thai were identified through searches of the databases CINAHL, MEDLINE, EMBASE, PsycINFO, and Thai LIS, as well as through manual searching.

Methodologically high-quality research articles were included if they addressed the promotion of active ageing and related concepts, the impact of mental disorders on active ageing and related concepts, the perspective of older people regarding active ageing, and issues related to working with older people with mental health problems living in the community.

Results

A total of 18 articles were included. The findings show that there is little evidence regarding the promotion of active ageing in older people with mental disorders.

Older people with mental disorders were less likely to achieve successful ageing compared with those without mental disorders, suggesting they need support from health care providers. However, there are several barriers to care and working with older people with mental disorders at the community level.

Conclusions

Of concern is that health professionals focus on the physical health of older people while mental health issues are overlooked.

Reference

Kenbubpha, K., Higgins, I., Chan, S.W-C. & Wilson, A. (2020) Promoting active ageing in older people with mental disorders living in the community: An integrative review. International Journal of Nursing Practice. 24(3):e12624. doi: 10.1111/ijn.12624. Epub 2018 Mar 30.

Mitochondria & Mental Disorders: Is There a Link?

Research Paper Title

Mitochondrial Involvement in Mental Disorders: Energy Metabolism and Genetic and Environmental Factors.

Background

Mental disorders, such as major depressive disorder (MDD), bipolar disorder (BD), and schizophrenia (SZ), are generally characterised by a combination of abnormal thoughts, perceptions, emotions, behaviour, and relationships with others.

Multiple risk factors incorporating genetic and environmental susceptibility are associated with development of these disorders.

Mitochondria have a central role in the energy metabolism, and the literature suggests energy metabolism abnormalities are widespread in the brains of subjects with MDD, BPD, and SZ.

Numerous studies have shown altered expressions of mitochondria-related genes in these mental disorders.

In addition, environmental factors for these disorders, such as stresses, have been suggested to induce mitochondrial abnormalities.

Moreover, animal studies have suggested that interactions of altered expression of mitochondria-related genes and environmental factors might be involved in mental disorders.

Further investigations into interactions of mitochondrial abnormalities with environmental factors are required to elucidate of the pathogenesis of these mental disorders.

Reference

Iwata, K. (2020) Mitochondrial Involvement in Mental Disorders: Energy Metabolism and Genetic and Environmental Factors. Advances in Experimental Medicine and Biology. doi: 10.1007/978-3-030-05542-4_3.

Can Exercise & Physical Activity Induce Improvements for Mental Disorders?

Research Paper Title

Exercise and physical activity in mental disorders: clinical and experimental evidence.

Background

Several epidemiological studies have shown that exercise (EX) and physical activity (PA) can prevent or delay the onset of different mental disorders, and have therapeutic benefits when used as sole or adjunct treatment in mental disorders.

This review summarises studies that used EX interventions in patients with anxiety, affective, eating, and substance use disorders, as well as schizophrenia and dementia/mild cognitive impairment.

Despite several decades of clinical evidence with EX interventions, controlled studies are sparse in most disorder groups.

Preliminary evidence suggests that PA/EX can induce improvements in physical, subjective and disorder-specific clinical outcomes.

Potential mechanisms of action are discussed, as well as implications for psychiatric research and practice.

Reference

Zschucke, E., Gaudlitz, K. & Strohle, A. (2020) Exercise and physical activity in mental disorders: clinical and experimental evidence. Journal of Preventive Medicine and Public Health. 46 Suppl 1(Suppl 1), pp.S12-21. doi: 10.3961/jpmph.2013.46.S.S12. Epub 2013 Jan 30.