What are Personality Disorders?

Introduction

Personality disorders (PD) are a class of mental disorders characterised by enduring maladaptive patterns of behaviour, cognition, and inner experience, exhibited across many contexts and deviating from those accepted by the individual’s culture.

These patterns develop early, are inflexible, and are associated with significant distress or disability. The definitions may vary somewhat, according to source, and remain a matter of controversy. Official criteria for diagnosing personality disorders are listed in the fifth chapter of the International Classification of Diseases (ICD) and in the American Psychiatric Association’s Diagnostic and Statistical Manual of Mental Disorders (DSM).

Personality, defined psychologically, is the set of enduring behavioural and mental traits that distinguish individual humans. Hence, PDs are defined by experiences and behaviours that deviate from social norms and expectations. Those diagnosed with a PD may experience difficulties in cognition, emotiveness, interpersonal functioning, or impulse control. In general, PDs are diagnosed in 40-60% of psychiatric patients, making them the most frequent of psychiatric diagnoses.

PDs are characterised by an enduring collection of behavioural patterns often associated with considerable personal, social, and occupational disruption. PDs are also inflexible and pervasive across many situations, largely due to the fact that such behaviour may be ego-syntonic (i.e. the patterns are consistent with the ego integrity of the individual) and are therefore perceived to be appropriate by that individual. In addition, people with personality disorders often lack insight into their condition and so refrain from seeking treatment. This behaviour can result in maladaptive coping skills and may lead to personal problems that induce extreme anxiety, distress, or depression and result in impaired psychosocial functioning. These behaviour patterns are typically recognised by adolescence, the beginning of adulthood or sometimes even childhood and often have a pervasive negative impact on the quality of life.

While emerging treatments, such as dialectical behaviour therapy, have demonstrated efficacy in treating PDs, such as borderline personality disorder, PDs are associated with considerable stigma in popular and clinical discourse alike. Despite various methodological schemas designed to categorise PDs, many issues occur with classifying a personality disorder because the theory and diagnosis of such disorders occur within prevailing cultural expectations; thus, their validity is contested by some experts on the basis of inevitable subjectivity. They argue that the theory and diagnosis of PDs are based strictly on social, or even sociopolitical and economic considerations.

Refer to Personality Disorder Not Otherwise Specified.

Brief History

Before the 20th Century

Personality disorder is a term with a distinctly modern meaning, owing in part to its clinical usage and the institutional character of modern psychiatry. The currently accepted meaning must be understood in the context of historical changing classification systems such as DSM-IV and its predecessors. Although highly anachronistic, and ignoring radical differences in the character of subjectivity and social relations, some have suggested similarities to other concepts going back to at least the ancient Greeks.  For example, the Greek philosopher Theophrastus described 29 ‘character’ types that he saw as deviations from the norm, and similar views have been found in Asian, Arabic and Celtic cultures. A long-standing influence in the Western world was Galen’s concept of personality types, which he linked to the four humours proposed by Hippocrates.

Such views lasted into the eighteenth century, when experiments began to question the supposed biologically based humours and ‘temperaments’. Psychological concepts of character and ‘self’ became widespread. In the nineteenth century, ‘personality’ referred to a person’s conscious awareness of their behaviour, a disorder of which could be linked to altered states such as dissociation. This sense of the term has been compared to the use of the term ‘multiple personality disorder’ in the first versions of the DSM.

Physicians in the early nineteenth century started to diagnose forms of insanity involving disturbed emotions and behaviours but seemingly without significant intellectual impairment or delusions or hallucinations. Philippe Pinel referred to this as ‘ manie sans délire ‘ – mania without delusions – and described a number of cases mainly involving excessive or inexplicable anger or rage. James Cowles Prichard advanced a similar concept he called moral insanity, which would be used to diagnose patients for some decades. ‘Moral’ in this sense referred to affect (emotion or mood) rather than ethics, but it was arguably based in part on religious, social and moral beliefs, with a pessimism about medical intervention so social control should take precedence. These categories were much different and broader than later definitions of personality disorder, while also being developed by some into a more specific meaning of moral degeneracy akin to later ideas about ‘psychopaths’. Separately, Richard von Krafft-Ebing popularised the terms sadism and masochism, as well as homosexuality, as psychiatric issues.

The German psychiatrist Koch sought to make the moral insanity concept more scientific, and in 1891 suggested the phrase ‘psychopathic inferiority’, theorised to be a congenital disorder. This referred to continual and rigid patterns of misconduct or dysfunction in the absence of apparent mental retardation or illness, supposedly without a moral judgement. Described as deeply rooted in his Christian faith, his work established the concept of personality disorder as used today.

20th century

In the early 20th century, another German psychiatrist, Emil Kraepelin, included a chapter on psychopathic inferiority in his influential work on clinical psychiatry for students and physicians. He suggested six types:

  • Excitable;
  • Unstable;
  • Eccentric;
  • Liar;
  • Swindler; and
  • Quarrelsome.

The categories were essentially defined by the most disordered criminal offenders observed, distinguished between criminals by impulse, professional criminals, and morbid vagabonds who wandered through life. Kraepelin also described three paranoid (meaning then delusional) disorders, resembling later concepts of schizophrenia, delusional disorder and paranoid personality disorder. A diagnostic term for the latter concept would be included in the DSM from 1952, and from 1980 the DSM would also include schizoid, schizotypal; interpretations of earlier (1921) theories of Ernst Kretschmer led to a distinction between these and another type later included in the DSM, avoidant personality disorder.

In 1933 Russian psychiatrist Pyotr Borisovich Gannushkin published his book Manifestations of Psychopathies: Statics, Dynamics, Systematic Aspects, which was one of the first attempts to develop a detailed typology of psychopathies. Regarding maladaptation, ubiquity, and stability as the three main symptoms of behavioural pathology, he distinguished nine clusters of psychopaths: cycloids (including constitutionally depressive, constitutionally excitable, cyclothymics, and emotionally labile), asthenics (including psychasthenics), schizoids (including dreamers), paranoiacs (including fanatics), epileptoids, hysterical personalities (including pathological liars), unstable psychopaths, antisocial psychopaths, and constitutionally stupid. Some elements of Gannushkin’s typology were later incorporated into the theory developed by a Russian adolescent psychiatrist, Andrey Yevgenyevich Lichko, who was also interested in psychopathies along with their milder forms, the so-called accentuations of character.

In 1939, psychiatrist David Henderson published a theory of ‘psychopathic states’ that contributed to popularly linking the term to anti-social behaviour. Hervey M. Cleckley’s 1941 text, The Mask of Sanity, based on his personal categorisation of similarities he noted in some prisoners, marked the start of the modern clinical conception of psychopathy and its popularist usage.

Towards the mid 20th century, psychoanalytic theories were coming to the fore based on work from the turn of the century being popularized by Sigmund Freud and others. This included the concept of character disorders, which were seen as enduring problems linked not to specific symptoms but to pervasive internal conflicts or derailments of normal childhood development. These were often understood as weaknesses of character or wilful deviance, and were distinguished from neurosis or psychosis. The term ‘borderline’ stems from a belief some individuals were functioning on the edge of those two categories, and a number of the other personality disorder categories were also heavily influenced by this approach, including dependent, obsessive-compulsive and histrionic, the latter starting off as a conversion symptom of hysteria particularly associated with women, then a hysterical personality, then renamed histrionic personality disorder in later versions of the DSM. A passive aggressive style was defined clinically by Colonel William Menninger during World War II in the context of men’s reactions to military compliance, which would later be referenced as a personality disorder in the DSM. Otto Kernberg was influential with regard to the concepts of borderline and narcissistic personalities later incorporated in 1980 as disorders into the DSM.

Meanwhile, a more general personality psychology had been developing in academia and to some extent clinically. Gordon Allport published theories of personality traits from the 1920s – and Henry Murray advanced a theory called personology, which influenced a later key advocate of personality disorders, Theodore Millon. Tests were developing or being applied for personality evaluation, including projective tests such as the Rorshach, as well as questionnaires such as the Minnesota Multiphasic Personality Inventory. Around mid-century, Hans Eysenck was analysing traits and personality types, and psychiatrist Kurt Schneider was popularising a clinical use in place of the previously more usual terms ‘character’, ‘temperament’ or ‘constitution’.

American psychiatrists officially recognised concepts of enduring personality disturbances in the first Diagnostic and Statistical Manual of Mental Disorders in the 1950s, which relied heavily on psychoanalytic concepts. Somewhat more neutral language was employed in the DSM-II in 1968, though the terms and descriptions had only a slight resemblance to current definitions. The DSM-III published in 1980 made some major changes, notably putting all personality disorders onto a second separate ‘axis’ along with mental retardation, intended to signify more enduring patterns, distinct from what were considered axis one mental disorders. ‘Inadequate’ and ‘asthenic’ personality disorder’ categories were deleted, and others were expanded into more types, or changed from being personality disorders to regular disorders. Sociopathic personality disorder, which had been the term for psychopathy, was renamed Antisocial Personality Disorder. Most categories were given more specific ‘operationalised’ definitions, with standard criteria psychiatrists could agree on to conduct research and diagnose patients. In the DSM-III revision, self-defeating personality disorder and sadistic personality disorder were included as provisional diagnoses requiring further study. They were dropped in the DSM-IV, though a proposed ‘depressive personality disorder’ was added; in addition, the official diagnosis of passive-aggressive personality disorder was dropped, tentatively renamed ‘negativistic personality disorder.’

International differences have been noted in how attitudes have developed towards the diagnosis of personality disorder. Kurt Schneider argued they were ‘abnormal varieties of psychic life’ and therefore not necessarily the domain of psychiatry, a view said to still have influence in Germany today. British psychiatrists have also been reluctant to address such disorders or consider them on par with other mental disorders, which has been attributed partly to resource pressures within the National Health Service, as well as to negative medical attitudes towards behaviours associated with personality disorders. In the US, the prevailing healthcare system and psychanalytic tradition has been said to provide a rationale for private therapists to diagnose some personality disorders more broadly and provide ongoing treatment for them.

Epidemiology

The prevalence of personality disorder in the general community was largely unknown until surveys starting from the 1990s. In 2008 the median rate of diagnosable PD was estimated at 10.6%, based on six major studies across three nations. This rate of around one in ten, especially as associated with high use of services, is described as a major public health concern requiring attention by researchers and clinicians.

The prevalence of individual personality disorders ranges from about 2% to 3% for the more common varieties, such as schizotypal, antisocial, borderline, and histrionic, to 0.5-1% for the least common, such as narcissistic and avoidant.

A screening survey across 13 countries by the WHO using DSM-IV criteria, reported in 2009 a prevalence estimate of around 6% for personality disorders. The rate sometimes varied with demographic and socioeconomic factors, and functional impairment was partly explained by co-occurring mental disorders. In the US, screening data from the National Comorbidity Survey Replication between 2001 and 2003, combined with interviews of a subset of respondents, indicated a population prevalence of around 9% for personality disorders in total. Functional disability associated with the diagnoses appeared to be largely due to co-occurring mental disorders (Axis I in the DSM).

A UK national epidemiological study (based on DSM-IV screening criteria), reclassified into levels of severity rather than just diagnosis, reported in 2010 that the majority of people show some personality difficulties in one way or another (short of threshold for diagnosis), while the prevalence of the most complex and severe cases (including meeting criteria for multiple diagnoses in different clusters) was estimated at 1.3%. Even low levels of personality symptoms were associated with functional problems, but the most severely in need of services was a much smaller group.

Personality disorders (especially Cluster A) are also very common among homeless people.

There are some sex differences in the frequency of personality disorders which are shown below (type of PD/predominant gender):

  •  Paranoid personality disorder: Male.
  • Schizoid personality disorder: Male.
  • Schizotypal personality disorder: Male.
  • Antisocial personality disorder: Male.
  • Borderline personality disorder: Female.
  • Histrionic personality disorder: Female.
  • Narcissistic personality disorder: Male.
  • Avoidant personality disorder: Male.
  • Dependent personality disorder: Female.
  • Depressive personality disorder: Female.
  • Passive–aggressive personality disorder: Male.
  • Obsessive-compulsive personality disorder: Male.
  • Self-defeating personality disorder: Female.
  • Sadistic personality disorder: Male.

Classification

The two relevant major systems of classification are:

The ICD system is a collection of numerical codes that have been assigned to all known clinical disease states, which provides uniform terminology for medical records, billing, and research purposes. The DSM defines psychiatric diagnoses based on research and expert consensus, and its content informs the ICD-10 classifications. Both have deliberately merged their diagnoses to some extent, but some differences remain. For example, ICD-10 does not include narcissistic personality disorder as a distinct category, while DSM-5 does not include enduring personality change after catastrophic experience or after psychiatric illness. ICD-10 classifies the DSM-5 schizotypal personality disorder as a form of schizophrenia rather than as a personality disorder. There are accepted diagnostic issues and controversies with regard to distinguishing particular personality disorder categories from each other.

General Criteria

Both diagnostic systems provide a definition and six criteria for a general personality disorder. These criteria should be met by all personality disorder cases before a more specific diagnosis can be made.

The ICD-10 lists these general guideline criteria:

  • Markedly disharmonious attitudes and behaviour, generally involving several areas of functioning, e.g. affectivity, arousal, impulse control, ways of perceiving and thinking, and style of relating to others;
  • The abnormal behaviour pattern is enduring, of long standing, and not limited to episodes of mental illness;
  • The abnormal behaviour pattern is pervasive and clearly maladaptive to a broad range of personal and social situations;
  • The above manifestations always appear during childhood or adolescence and continue into adulthood;
  • The disorder leads to considerable personal distress but this may only become apparent late in its course;
  • The disorder is usually, but not invariably, associated with significant problems in occupational and social performance.

The ICD adds: “For different cultures it may be necessary to develop specific sets of criteria with regard to social norms, rules and obligations.”

In DSM-5, any personality disorder diagnosis must meet the following criteria:

  • An enduring pattern of inner experience and behaviour that deviates markedly from the expectations of the individual’s culture. This pattern is manifested in two (or more) of the following areas:
    • Cognition (i.e. ways of perceiving and interpreting self, other people, and events).
    • Affectivity (i.e. the range, intensity, lability, and appropriateness of emotional response).
    • Interpersonal functioning.
    • Impulse control.
  • The enduring pattern is inflexible and pervasive across a broad range of personal and social situations.
  • The enduring pattern leads to clinically significant distress or impairment in social, occupational, or other important areas of functioning.
  • The pattern is stable and of long duration, and its onset can be traced back at least to adolescence or early adulthood.
  • The enduring pattern is not better explained as a manifestation or consequence of another mental disorder.
  • The enduring pattern is not attributable to the physiological effects of a substance (e.g. a drug of abuse, a medication) or another medical condition (e.g. head trauma).

In ICD-10

Chapter V in the ICD-10 contains the mental and behavioural disorders and includes categories of personality disorder and enduring personality changes. They are defined as ingrained patterns indicated by inflexible and disabling responses that significantly differ from how the average person in the culture perceives, thinks, and feels, particularly in relating to others.

The specific personality disorders are: paranoid, schizoid, dissocial, emotionally unstable (borderline type and impulsive type), histrionic, anankastic, anxious (avoidant) and dependent.

Besides the ten specific PD, there are the following categories:

  • Other specific personality disorders (involves PD characterised as eccentric, haltlose, immature, narcissistic, passive-aggressive, or psychoneurotic).
  • Personality disorder, unspecified (includes “character neurosis” and “pathological personality”).
  • Mixed and other personality disorders (defined as conditions that are often troublesome but do not demonstrate the specific pattern of symptoms in the named disorders).
  • Enduring personality changes, not attributable to brain damage and disease (this is for conditions that seem to arise in adults without a diagnosis of personality disorder, following catastrophic or prolonged stress or other psychiatric illness).

In ICD-11

In the proposed revision of ICD-11, all discrete personality disorder diagnoses will be removed and replaced by the single diagnosis “personality disorder”. Instead, there will be specifiers called “prominent personality traits” and the possibility to classify degrees of severity ranging from “mild”, “moderate”, and “severe” based on the dysfunction in interpersonal relationships and everyday life of the patient.

There are six prominent personality traits/patterns categorised by the ICD-11:

  • Negative affectivity (“tendency to experience a broad range of negative emotions.”).
  • Detachment (“tendency to maintain interpersonal distance (social detachment) and emotional distance (emotional detachment).”).
  • Dissociality (“disregard for the rights and feelings of others, encompassing both self-centredness and lack of empathy.” Equivalent to the DSM-5 classification of antisocial personality disorder.).
  • Disinhibition (“tendency to act rashly based on immediate external or internal stimuli (i.e., sensations, emotions, thoughts), without consideration of potential negative consequences.”).
  • Anankastia (“narrow focus on one’s rigid standard of perfection and of right and wrong, and on controlling one’s own and others’ behaviour and controlling situations to ensure conformity to these standards.” Equivalent to the DSM-5 classification of obsessive-compulsive personality disorder.),
  • Borderline pattern (“pattern of personality disturbance is characterised by a pervasive pattern of instability of interpersonal relationships, self-image, and affects, and marked impulsivity”. Equivalent to the DSM-5 classification of borderline personality disorder.),

In DSM-5

The most recent fifth edition of the Diagnostic and Statistical Manual of Mental Disorders stresses that a personality disorder is an enduring and inflexible pattern of long duration leading to significant distress or impairment and is not due to use of substances or another medical condition. The DSM-5 lists personality disorders in the same way as other mental disorders, rather than on a separate ‘axis’, as previously.

DSM-5 lists ten specific personality disorders: paranoid, schizoid, schizotypal, antisocial, borderline, histrionic, narcissistic, avoidant, dependent and obsessive-compulsive personality disorder.

The DSM-5 also contains three diagnoses for personality patterns not matching these ten disorders, but nevertheless exhibit characteristics of a personality disorder:

  • Personality change due to another medical condition – personality disturbance due to the direct effects of a medical condition.
  • Other specified personality disorder – general criteria for a personality disorder are met but fails to meet the criteria for a specific disorder, with the reason given.
  • Unspecified personality disorder – general criteria for a personality disorder are met but the personality disorder is not included in the DSM-5 classification.

Personality Clusters

The specific personality disorders are grouped into the following three clusters based on descriptive similarities:

Cluster A (Odd or Eccentric Disorders)

Cluster A personality disorders are often associated with schizophrenia: in particular, schizotypal personality disorder shares some of its hallmark symptoms with schizophrenia, e.g., acute discomfort in close relationships, cognitive or perceptual distortions, and eccentricities of behaviour. However, people diagnosed with odd-eccentric personality disorders tend to have a greater grasp on reality than those with schizophrenia. Patients suffering from these disorders can be paranoid and have difficulty being understood by others, as they often have odd or eccentric modes of speaking and an unwillingness and inability to form and maintain close relationships. Though their perceptions may be unusual, these anomalies are distinguished from delusions or hallucinations as people suffering from these would be diagnosed with other conditions. Significant evidence suggests a small proportion of people with Cluster A personality disorders, especially schizotypal personality disorder, have the potential to develop schizophrenia and other psychotic disorders. These disorders also have a higher probability of occurring among individuals whose first-degree relatives have either schizophrenia or a Cluster A personality disorder.

Cluster B (Dramatic, Emotional or Erratic Disorders)

  • Antisocial personality disorder: pervasive pattern of disregard for and violation of the rights of others, lack of empathy, bloated self-image, manipulative and impulsive behaviour.
  • Borderline personality disorder: pervasive pattern of abrupt emotional outbursts, altered empathy, instability in relationships, self-image, identity, behaviour and affect, often leading to self-harm and impulsivity.
  • Histrionic personality disorder: pervasive pattern of attention-seeking behaviour, excessive emotions, and egocentrism.
  • Narcissistic personality disorder: pervasive pattern of superior grandiosity, need for admiration, and a perceived or real lack of empathy. In a more severe expression, narcissistic personality disorder may show evidence of paranoia, aggression, psychopathy, and sadistic personality disorder, which is known as malignant narcissism.

Cluster C (Anxious or Fearful Disorders)

Other Personality Types

Some types of personality disorder were in previous versions of the diagnostic manuals but have been deleted. Examples include sadistic personality disorder (pervasive pattern of cruel, demeaning, and aggressive behaviour) and self-defeating personality disorder or masochistic personality disorder (characterised by behaviour consequently undermining the person’s pleasure and goals). They were listed in the DSM-III-R appendix as “Proposed diagnostic categories needing further study” without specific criteria. The psychologist Theodore Millon and others consider some relegated diagnoses to be equally valid disorders, and may also propose other personality disorders or subtypes, including mixtures of aspects of different categories of the officially accepted diagnoses.

Millon’s Description

Psychologist Theodore Millon, who has written numerous popular works on personality, proposed the following description of personality disorders:

Type of Personality DisorderDescription
ParanoidGuarded, defensive, distrustful and suspicious. Hypervigilant to the motives of others to undermine or do harm. Always seeking confirmatory evidence of hidden schemes. Feel righteous, but persecuted. Experience a pattern of pervasive distrust and suspicion of others that lasts a long time. They are generally difficult to work with and are very hard to form relationships with. They are also known to be somewhat short-tempered.
SchizoidApathetic, indifferent, remote, solitary, distant, humourless, contempt, odd fantasies. Neither desire nor need human attachments. Withdrawn from relationships and prefer to be alone. Little interest in others, often seen as a loner. Minimal awareness of the feelings of themselves or others. Few drives or ambitions, if any. Is an uncommon condition in which people avoid social activities and consistently shy away from interaction with others. It affects more males than females. To others, they may appear somewhat dull or humourless. Because they don’t tend to show emotion, they may appear as though they don’t care about what’s going on around them.
SchizotypalEccentric, self-estranged, bizarre, absent. Exhibit peculiar mannerisms and behaviours. Think they can read thoughts of others. Preoccupied with odd daydreams and beliefs. Blur line between reality and fantasy. Magical thinking and strange beliefs. People with schizotypal personality disorder are often described as odd or eccentric and usually have few, if any, close relationships. They think others think negatively of them.
AntisocialImpulsive, irresponsible, deviant, unruly. Act without due consideration. Meet social obligations only when self-serving. Disrespect societal customs, rules, and standards. See themselves as free and independent. People with antisocial personality disorder depict a long pattern of disregard for other people’s rights. They often cross the line and violate these rights.
BorderlineUnpredictable, egocentric, emotionally unstable. Frantically fears abandonment and isolation. Experience rapidly fluctuating moods. Shift rapidly between loving and hating. See themselves and others alternatively as all-good and all-bad. Unstable and frequently changing moods. People with borderline personality disorder have a pervasive pattern of instability in interpersonal relationships.
HistrionicHysteria, dramatic, seductive, shallow, egocentric, attention-seeking, vain. Overreact to minor events. Exhibitionistic as a means of securing attention and favours. See themselves as attractive and charming. Constantly seeking others’ attention. Disorder is characterised by constant attention-seeking, emotional overreaction, and suggestibility. Their tendency to over-dramatise may impair relationships and lead to depression, but they are often high-functioning.
NarcissisticEgotistical, arrogant, grandiose, insouciant. Preoccupied with fantasies of success, beauty, or achievement. See themselves as admirable and superior, and therefore entitled to special treatment. Is a mental disorder in which people have an inflated sense of their own importance and a deep need for admiration. Those with narcissistic personality disorder believe that they are superior to others and have little regard for other people’s feelings.
AvoidantHesitant, self-conscious, embarrassed, anxious. Tense in social situations due to fear of rejection. Plagued by constant performance anxiety. See themselves as inept, inferior, or unappealing. They experience long-standing feelings of inadequacy and are very sensitive of what others think about them.
DependentHelpless, incompetent, submissive, immature. Withdrawn from adult responsibilities. See themselves as weak or fragile. Seek constant reassurance from stronger figures. They have the need to be taken care of by a person. They fear being abandoned or separated from important people in their life.
Obsessive-CompulsiveRestrained, conscientious, respectful, rigid. Maintain a rule-bound lifestyle. Adhere closely to social conventions. See the world in terms of regulations and hierarchies. See themselves as devoted, reliable, efficient, and productive.
DepressiveSombre, discouraged, pessimistic, brooding, fatalistic. Present themselves as vulnerable and abandoned. Feel valueless, guilty, and impotent. Judge themselves as worthy only of criticism and contempt. Hopeless, suicidal, restless. This disorder can lead to aggressive acts and hallucinations.
Passive-Aggressive (Negativistic)Resentful, contrary, sceptical, discontented. Resist fulfilling others’ expectations. Deliberately inefficient. Vent anger indirectly by undermining others’ goals. Alternately moody and irritable, then sullen and withdrawn. Withhold emotions. Will not communicate when there is something problematic to discuss.
SadisticExplosively hostile, abrasive, cruel, dogmatic. Liable to sudden outbursts of rage. Gain satisfaction through dominating, intimidating and humiliating others. They are opinionated and closed-minded. Enjoy performing brutal acts on others. Find pleasure in abusing others. Would likely engage in a sadomasochist relationship, but will not play the role of a masochist.
Self-Defeating (Masochistic)Deferential, pleasure-phobic, servile, blameful, self-effacing. Encourage others to take advantage of them. Deliberately defeat own achievements. Seek condemning or mistreatful partners. They are suspicious of people who treat them well. Would likely engage in a sadomasochist relationship.

Additional Factors

In addition to classifying by category and cluster, it is possible to classify personality disorders using additional factors such as severity, impact on social functioning, and attribution.

Severity

This involves both the notion of personality difficulty as a measure of subthreshold scores for personality disorder using standard interviews and the evidence that those with the most severe personality disorders demonstrate a “ripple effect” of personality disturbance across the whole range of mental disorders. In addition to subthreshold (personality difficulty) and single cluster (simple personality disorder), this also derives complex or diffuse personality disorder (two or more clusters of personality disorder present) and can also derive severe personality disorder for those of greatest risk.

Dimensional System of Classifying Personality Disorders

Level of SeverityDescriptionDefinition by Categorical System
0No personality disorderDoes not meet actual or subthreshold criteria for any personality disorder.
1Personality difficultyMeets sub-threshold criteria for one or several personality disorders.
2Simple personality disorderMeets actual criteria for one or more personality disorders within the same cluster.
3Complex (diffuse) personality disorderMeets actual criteria for one or more personality disorders within more than one cluster.
4Severe personality disorderMeets criteria for creation of severe disruption to both individual and to many in society.

There are several advantages to classifying personality disorder by severity:

  • It not only allows for but also takes advantage of the tendency for personality disorders to be comorbid with each other.
  • It represents the influence of personality disorder on clinical outcome more satisfactorily than the simple dichotomous system of no personality disorder versus personality disorder.
  • This system accommodates the new diagnosis of severe personality disorder, particularly “dangerous and severe personality disorder” (DSPD).

Effect on Social Functioning

Social function is affected by many other aspects of mental functioning apart from that of personality. However, whenever there is persistently impaired social functioning in conditions in which it would normally not be expected, the evidence suggests that this is more likely to be created by personality abnormality than by other clinical variables. The Personality Assessment Schedule gives social function priority in creating a hierarchy in which the personality disorder creating the greater social dysfunction is given primacy over others in a subsequent description of personality disorder.

Attribution

Many who have a personality disorder do not recognise any abnormality and defend valiantly their continued occupancy of their personality role. This group have been termed the Type R, or treatment-resisting personality disorders, as opposed to the Type S or treatment-seeking ones, who are keen on altering their personality disorders and sometimes clamour for treatment. The classification of 68 personality disordered patients on the caseload of an assertive community team using a simple scale showed a 3 to 1 ratio between Type R and Type S personality disorders with Cluster C personality disorders being significantly more likely to be Type S, and paranoid and schizoid (Cluster A) personality disorders significantly more likely to be Type R than others.

Presentation

Comorbidity

There is a considerable personality disorder diagnostic co-occurrence. Patients who meet the DSM-IV-TR diagnostic criteria for one personality disorder are likely to meet the diagnostic criteria for another. Diagnostic categories provide clear, vivid descriptions of discrete personality types but the personality structure of actual patients might be more accurately described by a constellation of maladaptive personality traits.

Impact on Functioning

It is generally assumed that all personality disorders are linked to impaired functioning and a reduced quality of life (QoL) because that is a basic diagnostic requirement. But research shows that this may be true only for some types of personality disorder.

In several studies, higher disability and lower QoL were predicted by avoidant, dependent, schizoid, paranoid, schizotypal and antisocial personality disorder. This link is particularly strong for avoidant, schizotypal and borderline PD. However, obsessive-compulsive PD was not related to a compromised QoL or dysfunction. A prospective study reported that all PD were associated with significant impairment 15 years later, except for obsessive compulsive and narcissistic personality disorder.

One study investigated some aspects of “life success” (status, wealth and successful intimate relationships). It showed somewhat poor functioning for schizotypal, antisocial, borderline and dependent PD, schizoid PD had the lowest scores regarding these variables. Paranoid, histrionic and avoidant PD were average. Narcissistic and obsessive-compulsive PD, however, had high functioning and appeared to contribute rather positively to these aspects of life success.

There is also a direct relationship between the number of diagnostic criteria and quality of life. For each additional personality disorder criterion that a person meets there is an even reduction in quality of life.

Issues

In the Workplace

Depending on the diagnosis, severity and individual, and the job itself, personality disorders can be associated with difficulty coping with work or the workplace – potentially leading to problems with others by interfering with interpersonal relationships. Indirect effects also play a role; for example, impaired educational progress or complications outside of work, such as substance abuse and co-morbid mental disorders, can plague sufferers. However, personality disorders can also bring about above-average work abilities by increasing competitive drive or causing the sufferer to exploit his or her co-workers.

In 2005 and again in 2009, psychologists Belinda Board and Katarina Fritzon at the University of Surrey, UK, interviewed and gave personality tests to high-level British executives and compared their profiles with those of criminal psychiatric patients at Broadmoor Hospital in the UK. They found that three out of eleven personality disorders were actually more common in executives than in the disturbed criminals:

  • Histrionic personality disorder: including superficial charm, insincerity, egocentricity and manipulation
  • Narcissistic personality disorder: including grandiosity, self-focused lack of empathy for others, exploitativeness and independence.
  • Obsessive-compulsive personality disorder: including perfectionism, excessive devotion to work, rigidity, stubbornness and dictatorial tendencies.

According to leadership academic Manfred F.R. Kets de Vries, it seems almost inevitable that some personality disorders will be present in a senior management team.

In Children

Early stages and preliminary forms of personality disorders need a multi-dimensional and early treatment approach. Personality development disorder is considered to be a childhood risk factor or early stage of a later personality disorder in adulthood. In addition, in Robert F. Krueger’s review of their research indicates that some children and adolescents do suffer from clinically significant syndromes that resemble adult personality disorders, and that these syndromes have meaningful correlates and are consequential. Much of this research has been framed by the adult personality disorder constructs from Axis II of the Diagnostic and Statistical Manual. Hence, they are less likely to encounter the first risk they described at the outset of their review: clinicians and researchers are not simply avoiding use of the PD construct in youth. However, they may encounter the second risk they described: under-appreciation of the developmental context in which these syndromes occur. That is, although PD constructs show continuity over time, they are probabilistic predictors; not all youths who exhibit PD symptomatology become adult PD cases.

Versus Mental Disorders

The disorders in each of the three clusters may share with each other underlying common vulnerability factors involving cognition, affect and impulse control, and behavioural maintenance or inhibition, respectively. But they may also have a spectrum relationship to certain syndromal mental disorders:

  • Paranoid, schizoid or schizotypal personality disorders may be observed to be premorbid antecedents of delusional disorders or schizophrenia.
  • Borderline personality disorder is seen in association with mood and anxiety disorders, with impulse-control disorders, eating disorders, ADHD, or a substance use disorder.
  • Avoidant personality disorder is seen with social anxiety disorder.

Versus Normal Personality

The issue of the relationship between normal personality and personality disorders is one of the important issues in personality and clinical psychology. The personality disorders classification (DSM-5 and ICD-10) follows a categorical approach that views personality disorders as discrete entities that are distinct from each other and from normal personality. In contrast, the dimensional approach is an alternative approach that personality disorders represent maladaptive extensions of the same traits that describe normal personality.

Thomas Widiger and his collaborators have contributed to this debate significantly. He discussed the constraints of the categorical approach and argued for the dimensional approach to the personality disorders. Specifically, he proposed the Five Factor Model of personality as an alternative to the classification of personality disorders. For example, this view specifies that Borderline Personality Disorder can be understood as a combination of emotional lability (i.e. high neuroticism), impulsivity (i.e. low conscientiousness), and hostility (i.e. low agreeableness). Many studies across cultures have explored the relationship between personality disorders and the Five Factor Model. This research has demonstrated that personality disorders largely correlate in expected ways with measures of the Five Factor Model and has set the stage for including the Five Factor Model within DSM-5.

In clinical practice, individuals are generally diagnosed by an interview with a psychiatrist based on a mental status examination, which may take into account observations by relatives and others. One tool of diagnosing personality disorders is a process involving interviews with scoring systems. The patient is asked to answer questions, and depending on their answers, the trained interviewer tries to code what their responses were. This process is fairly time-consuming.

As of 2002, there were over fifty published studies relating the five factor model (FFM) to personality disorders. Since that time, quite a number of additional studies have expanded on this research base and provided further empirical support for understanding the DSM personality disorders in terms of the FFM domains. In her seminal review of the personality disorder literature published in 2007, Lee Anna Clark asserted that “the five-factor model of personality is widely accepted as representing the higher-order structure of both normal and abnormal personality traits”.

The five factor model has been shown to significantly predict all 10 personality disorder symptoms and outperform the Minnesota Multiphasic Personality Inventory (MMPI) in the prediction of borderline, avoidant, and dependent personality disorder symptoms.

Research results examining the relationships between the FFM and each of the ten DSM personality disorder diagnostic categories are widely available. For example, in a study published in 2003 titled “The five-factor model and personality disorder empirical literature: A meta-analytic review”, the authors analysed data from 15 other studies to determine how personality disorders are different and similar, respectively, with regard to underlying personality traits. In terms of how personality disorders differ, the results showed that each disorder displays a FFM profile that is meaningful and predictable given its unique diagnostic criteria. With regard to their similarities, the findings revealed that the most prominent and consistent personality dimensions underlying a large number of the personality disorders are positive associations with neuroticism and negative associations with agreeableness.

Openness to Experience

At least three aspects of openness to experience are relevant to understanding personality disorders: cognitive distortions, lack of insight (means the ability to recognise one’s own mental illness here) and impulsivity. Problems related to high openness that can cause problems with social or professional functioning are excessive fantasising, peculiar thinking, diffuse identity, unstable goals and nonconformity with the demands of the society.

High openness is characteristic to schizotypal personality disorder (odd and fragmented thinking), narcissistic personality disorder (excessive self-valuation) and paranoid personality disorder (sensitivity to external hostility). Lack of insight (shows low openness) is characteristic to all personality disorders and could help explain the persistence of maladaptive behavioural patterns.

The problems associated with low openness are difficulties adapting to change, low tolerance for different worldviews or lifestyles, emotional flattening, alexithymia and a narrow range of interests. Rigidity is the most obvious aspect of (low) openness among personality disorders and that shows lack of knowledge of one’s emotional experiences. It is most characteristic of obsessive-compulsive personality disorder; the opposite of it known as impulsivity (here: an aspect of openness that shows a tendency to behave unusually or autistically) is characteristic of schizotypal and borderline personality disorders.

Causes

Currently, there are no definitive proven causes for personality disorders. However, there are numerous possible causes and known risk factors supported by scientific research that vary depending on the disorder, the individual, and the circumstance. Overall, findings show that genetic disposition and life experiences, such as trauma and abuse, play a key role in the development of personality disorders.

Child Abuse

Child abuse and neglect consistently show up as risk factors to the development of personality disorders in adulthood. A study looked at retrospective reports of abuse of participants that had demonstrated psychopathology throughout their life and were later found to have past experience with abuse. In a study of 793 mothers and children, researchers asked mothers if they had screamed at their children, and told them that they did not love them or threatened to send them away. Children who had experienced such verbal abuse were three times as likely as other children (who did not experience such verbal abuse) to have borderline, narcissistic, obsessive-compulsive or paranoid personality disorders in adulthood. The sexually abused group demonstrated the most consistently elevated patterns of psychopathology. Officially verified physical abuse showed an extremely strong correlation with the development of antisocial and impulsive behaviour. On the other hand, cases of abuse of the neglectful type that created childhood pathology were found to be subject to partial remission in adulthood.

Socioeconomic Status

Socioeconomic status has also been looked at as a potential cause for personality disorders. There is a strong association with low parental/neighbourhood socioeconomic status and personality disorder symptoms. In a 2015 publication from Bonn, Germany, which compared parental socioeconomic status and a child’s personality, it was seen that children who were from higher socioeconomic backgrounds were more altruistic, less risk seeking, and had overall higher IQs. These traits correlate with a low risk of developing personality disorders later on in life. In a study looking at female children who were detained for disciplinary actions found that psychological problems were most negatively associated with socioeconomic problems. Furthermore, social disorganisation was found to be inversely correlated with personality disorder symptoms.

Parenting

Evidence shows personality disorders may begin with parental personality issues. These cause the child to have their own difficulties in adulthood, such as difficulties reaching higher education, obtaining jobs, and securing dependable relationships. By either genetic or modelling mechanisms, children can pick up these traits. Additionally, poor parenting appears to have symptom elevating effects on personality disorders. More specifically, lack of maternal bonding has also been correlated with personality disorders. In a study comparing 100 healthy individuals to 100 borderline personality disorder patients, analysis showed that BPD patients were significantly more likely not to have been breastfed as a baby (42.4% in BPD vs. 9.2% in healthy controls). These researchers suggested this act may be essential in fostering maternal relationships. Additionally, findings suggest personality disorders show a negative correlation with two attachment variables: maternal availability and dependability. When left unfostered, other attachment and interpersonal problems occur later in life ultimately leading to development of personality disorders.

Genetics

Currently, genetic research for the understanding of the development of personality disorders is severely lacking. However, there are a few possible risk factors currently in discovery. Researchers are currently looking into genetic mechanisms for traits such as aggression, fear and anxiety, which are associated with diagnosed individuals. More research is being conducted into disorder specific mechanisms.

Malfunctioning Inner Brain – Hippocampus, Amygdala

Research shows a malfunctioning inner brain: hippocampus up to 18% smaller, a smaller amygdala, malfunctions in the striatum-nucleus accumbens and the cingulum neural pathways connecting them and taking care of the feedback loops on what to do with all the incoming information from the multiple senses; so what comes out is anti-social – not according to what is the social norm, socially acceptable and appropriate.

Management

Specific Approaches

There are many different forms (modalities) of treatment used for personality disorders:

  • Individual psychotherapy has been a mainstay of treatment. There are long-term and short-term (brief) forms.
  • Family therapy, including couples therapy.
  • Group therapy for personality dysfunction is probably the second most used.
  • Psychological-education may be used as an addition.
  • Self-help groups may provide resources for personality disorders.
  • Psychiatric medications for treating symptoms of personality dysfunction or co-occurring conditions.
  • Milieu therapy, a kind of group-based residential approach, has a history of use in treating personality disorders, including therapeutic communities.
  • The practice of mindfulness that includes developing the ability to be non-judgementally aware of unpleasant emotions appears to be a promising clinical tool for managing different types of personality disorders.

There are different specific theories or schools of therapy within many of these modalities. They may, for example, emphasize psychodynamic techniques, or cognitive or behavioural techniques. In clinical practice, many therapists use an ‘eclectic’ approach, taking elements of different schools as and when they seem to fit to an individual client. There is also often a focus on common themes that seem to be beneficial regardless of techniques, including attributes of the therapist (e.g. trustworthiness, competence, caring), processes afforded to the client (e.g. ability to express and confide difficulties and emotions), and the match between the two (e.g. aiming for mutual respect, trust and boundaries).

Response of Patients with Personality Disorders to Biological and Psychosocial Treatments

ClusterEvidence for Brain DysfunctionResponse to Biological TreatmentsResponse to Psychosocial Treatments
AEvidence for relationship to schizophrenia; otherwise none known.Schizotypal patients may improve on antipsychotic medication; otherwise not indicated.Poor. Supportive psychotherapy may help.
BEvidence for relationship to bipolar disorder; otherwise none known.Antidepressants, antipsychotics, or mood stabilizers may help for borderline personality; otherwise not indicated.Poor in antisocial personality. Variable in borderline, narcissistic, and histrionic personalities.
CEvidence for relationship to generalized anxiety disorder; otherwise none known.No direct response. Medications may help with comorbid anxiety and depression.Most common treatment for these disorders. Response variable.

Challenges

The management and treatment of personality disorders can be a challenging and controversial area, for by definition the difficulties have been enduring and affect multiple areas of functioning. This often involves interpersonal issues, and there can be difficulties in seeking and obtaining help from organisations in the first place, as well as with establishing and maintaining a specific therapeutic relationship. On the one hand, an individual may not consider themselves to have a mental health problem, while on the other, community mental health services may view individuals with personality disorders as too complex or difficult, and may directly or indirectly exclude individuals with such diagnoses or associated behaviours. The disruptiveness that people with personality disorders can create in an organisation makes these, arguably, the most challenging conditions to manage.

Apart from all these issues, an individual may not consider their personality to be disordered or the cause of problems. This perspective may be caused by the patient’s ignorance or lack of insight into their own condition, an ego-syntonic perception of the problems with their personality that prevents them from experiencing it as being in conflict with their goals and self-image, or by the simple fact that there is no distinct or objective boundary between ‘normal’ and ‘abnormal’ personalities. There is substantial social stigma and discrimination related to the diagnosis.

The term ‘personality disorder’ encompasses a wide range of issues, each with a different level of severity or disability; thus, personality disorders can require fundamentally different approaches and understandings. To illustrate the scope of the matter, consider that while some disorders or individuals are characterised by continual social withdrawal and the shunning of relationships, others may cause fluctuations in forwardness. The extremes are worse still: at one extreme lie self-harm and self-neglect, while at another extreme some individuals may commit violence and crime. There can be other factors such as problematic substance use or dependency or behavioural addictions. A person may meet the criteria for dissociative identity disorder (formerly “multiple personality disorder”) diagnoses and/or other mental disorders, either at particular times or continually, thus making coordinated input from multiple services a potential requirement.

Therapists in this area can become disheartened by lack of initial progress, or by apparent progress that then leads to setbacks. Clients may be perceived as negative, rejecting, demanding, aggressive or manipulative. This has been looked at in terms of both therapist and client; in terms of social skills, coping efforts, defence mechanisms, or deliberate strategies; and in terms of moral judgments or the need to consider underlying motivations for specific behaviours or conflicts. The vulnerabilities of a client, and indeed a therapist, may become lost behind actual or apparent strength and resilience. It is commonly stated that there is always a need to maintain appropriate professional personal boundaries, while allowing for emotional expression and therapeutic relationships. However, there can be difficulty acknowledging the different worlds and views that both the client and therapist may live with. A therapist may assume that the kinds of relationships and ways of interacting that make them feel safe and comfortable have the same effect on clients. As an example of one extreme, people who may have been exposed to hostility, deceptiveness, rejection, aggression or abuse in their lives, may in some cases be made confused, intimidated or suspicious by presentations of warmth, intimacy or positivity. On the other hand, reassurance, openness and clear communication are usually helpful and needed. It can take several months of sessions, and perhaps several stops and starts, to begin to develop a trusting relationship that can meaningfully address a client’s issues.

What is Phenacetin?

Introduction

Phenacetin (acetophenetidin, N-(4-ethoxyphenyl)acetamide) is a pain-relieving and fever-reducing drug, which was widely used following its introduction in 1887.

It was withdrawn from medicinal use as dangerous from the 1970s (e.g. withdrawn in Canada in 1973, and by the US Food and Drug Administration (FDA) in 1983).

Brief History

Phenacetin was introduced in 1887 in Elberfeld, Germany by German company Bayer, and was used principally as an analgesic; it was one of the first synthetic fever reducers to go on the market. It is also known historically to be one of the first non-opioid analgesics without anti-inflammatory properties.

Prior to World War One, Britain imported phenacetin from Germany. During the war, a team including Jocelyn Field Thorpe and Martha Annie Whiteley developed a synthesis in Britain.

Known Mechanism of Action

Phenacetin’s analgesic effects are due to its actions on the sensory tracts of the spinal cord. In addition, phenacetin has a depressant action on the heart, where it acts as a negative inotrope. It is an antipyretic, acting on the brain to decrease the temperature set point. It is also used to treat rheumatoid arthritis (subacute type) and intercostal neuralgia.

In vivo, one of two reactions occur. Usually Phenacitin’s ether is cleaved to leave paracetamol (acetaminophen), which is the clinically relevant analgesic. A minority of the time the acetyl group is removed from the amine, producing carcinogenic P-Phenetidine. This reaction is quite rare, however, as evidenced by the fact that the drug was on the market for almost 100 years before a statistical link was established, when Canada, followed by the United States, withdrew it from the market.

Preparation

The first synthesis was reported in 1878 by Harmon Northrop Morse.

Phenacetin may be synthesized as an example of the Williamson ether synthesis: ethyl iodide, paracetamol, and anhydrous potassium carbonate are heated in 2-butanone to give the crude product, which is recrystallised from water.

Uses

Phenacetin was widely used until the third quarter of the twentieth century, often in the form of an A.P.C., or “aspirin-phenacetin-caffeine” compound analgesic, as a remedy for fever and pain. An early formulation (1919) was Vincent’s APC in Australia.

In the United States, the FDA ordered the withdrawal of drugs containing phenacetin in November 1983, due to its carcinogenic and kidney-damaging properties. It was also banned in India. As a result, some branded, and previously phenacetin-based, preparations continued to be sold, but with the phenacetin replaced by safer alternatives. A popular brand of phenacetin was Roche’s Saridon, which was reformulated in 1983 to contain propyphenazone, paracetamol and caffeine. Coricidin was also reformulated without phenacetin. Paracetamol is a metabolite of phenacetin with similar analgesic and antipyretic effects, but the new formulation has not been found to have phenacetin’s carcinogenicity.

Phenacetin has been used as a cutting agent to adulterate cocaine in the UK and Canada, due to the similar physical properties.

Due to its low cost, phenacetin is used for research into the physical and refractive properties of crystals. It is an ideal compound for this type of research.

In Canada phenacetin is used as a laboratory reagent, and in a few hair dye preparations (as a stabiliser for hydrogen peroxide). While it is considered a prescription drug, no marketed drugs contain phenacetin.

Safety

Phenacetin, and products containing phenacetin, have been shown in an animal model to have the side effect and after-effect of carcinogenesis. In humans, many case reports have implicated products containing phenacetin in urothelial neoplasms, especially urothelial carcinoma of the renal pelvis. Phenacetin is classified by the International Agency for Research on Cancer (IARC) as carcinogenic to humans. In one prospective series, phenacetin was associated with an increased risk of death due to urologic or renal diseases, death due to cancers, and death due to cardiovascular diseases. In addition, people with glucose-6-phosphate dehydrogenase deficiency may experience acute haemolysis, or dissolution of blood cells, while taking this drug. Acute haemolysis is possible in the case of patients who develop an IgM response to phenacetin leading to immune complexes that bind to erythrocytes in blood. The erythrocytes are then lysed when the complexes activate the complement system.

Chronic use of phenacetin is known to lead to analgesic nephropathy characterized by renal papillary necrosis. This is a condition which results in destruction of some or all of the renal papillae in the kidneys. It is believed that the metabolite p-phenetidine is at least partly responsible for these effects.

One notable death that can possibly be attributed to the use of this drug was that of the aviation pioneer Howard Hughes. He had been using phenacetin extensively for the treatment of chronic pain; it was stated during his autopsy that phenacetin use may have been the cause of his kidney failure.

On This Day … 16 November

People (Births)

  • 1944 – Oliver Braddick, English psychologist and academic.

People (Deaths)

  • 1950 – Bob Smith, American physician and surgeon, co-founded Alcoholics Anonymous (b. 1879).

Oliver Braddick

Oliver John Braddick, FBA, FMedSci (born 16 November 1944) is a British developmental psychologist who is involved in research on infant visual perception. He frequently collaborates with his wife Janette Atkinson.

Braddick is Emeritus Professor of Experimental Psychology and was formerly head of the Department of Experimental Psychology at Oxford University from 2001 until his retirement in 2011. He attained a BA (1965) and PhD (1968) in Experimental Psychology at Trinity College, Cambridge. Between 1968 and 1969 he was a post-doctoral fellow in the laboratory of Lorrin Riggs, Brown University, US. In 1969 he returned to Cambridge as a University Demonstrator, proceeding to become a lecturer and then reader. By 1976, Braddick was an active member of the Cambridge Visual Development Unit, along with Janette Atkinson, his wife. The unit carried out pioneering research on the development of visual cortical function in infancy and in early visual screening. He also progressed understanding in binocular processes of both infants and adults. In 1993 Braddick moved to University College London, together with Janette Atkinson, as professors of Psychology. He proceeded to become head of the Psychology department in 1998. He was elected fellow of the Academy of Medical Sciences in 2001 and that same year appointed Head Professor of Psychology at the University of Oxford and fellow at Magdalen College, Oxford. In July 2012, it was announced that he had been elected as a Fellow of the British Academy, due to his contributions in the field of visual perception and its development in early childhood. Braddick is also a member of the Visual Development Unit at the University College of London and University of Oxford, a unit that specialises in child visual perception. He is a member of the editorial board for Current Biology.

Bob Smith

Robert Holbrook Smith (08 August 1879 to 16 November 1950), also known as Dr. Bob, was an American physician and surgeon who founded Alcoholics Anonymous with Bill Wilson (more commonly known as Bill W.).

Smith began drinking at college attending Dartmouth College in Hanover, New Hampshire. Early on he noticed that he could recover from drinking bouts quicker and easier than his classmates and that he never had headaches, which caused him to believe he was an alcoholic from the time he began drinking. Smith was a member of Kappa Kappa Kappa fraternity at Dartmouth. After graduation in 1902, he worked for three years selling hardware in Boston, Chicago, and Montreal and continued drinking heavily. He then returned to school to study medicine at the University of Michigan. By this time drinking had begun to affect him to the point where he began missing classes. His drinking caused him to leave school, but he returned and passed his examinations for his sophomore year. He transferred to Rush Medical College, but his alcoholism worsened to the point that his father was summoned to try to halt his downward trajectory. But his drinking increased and after a dismal showing during final examinations, the university required that he remain for two extra quarters and remain sober during that time as a condition of graduating.

After graduation, Smith became a hospital intern, and for two years he was able to stay busy enough to refrain from heavy drinking. He married Anne Robinson Ripley on 25 January 1915, and opened up his own office in Akron, Ohio, specialising in colorectal surgery and returned to heavy drinking. Recognising his problem, he checked himself into more than a dozen hospitals and sanitariums in an effort to stop his drinking. He was encouraged by the passage of Prohibition in 1919, but soon discovered that the exemption for medicinal alcohol, and bootleggers, could supply more than enough to continue his excessive drinking. For the next 17 years his life revolved around how to subvert his wife’s efforts to stop his drinking and obtain the alcohol he craved while trying to hold together a medical practice in order to support his family and his drinking.

In January 1933, Bob Smith attended a lecture by Frank Buchman, the founder of the Oxford Group. For the next two years he and Smith attended local meetings of the group in an effort to solve his alcoholism, but recovery eluded him until he met Bill Wilson on 12 May 1935. Wilson was an alcoholic who had learned how to stay sober, thus far only for some limited amounts of time, through the Oxford Group in New York, and was close to discovering long-term sobriety by helping other alcoholics. Wilson was in Akron on business that had proven unsuccessful and he was in fear of relapsing. Recognising the danger, he made inquiries about any local alcoholics he could talk to and was referred to Smith by Henrietta Seiberling, one of the leaders of the Akron Oxford Group. After talking to Wilson, Smith stopped drinking and invited Wilson to stay at his home. He relapsed almost a month later while attending a professional convention in Atlantic City. Returning to Akron on 09 June, he was given a few drinks by Wilson to avoid delirium tremens. He drank one beer the next morning to settle his nerves so he could perform an operation, which proved to be the last alcoholic drink he would ever have. The date, 10 June 1935, is celebrated as the anniversary of the founding of Alcoholics Anonymous.

Smith was called the “Prince of Twelfth Steppers” by Wilson because he helped more than 5,000 alcoholics before his death. He was able to stay sober from 10 June 1935, until his death in 1950 from colon cancer. He is buried at the Mount Peace Cemetery in Akron, Ohio.

Alcoholics Anonymous

Alcoholics Anonymous (AA) is an international fellowship requiring no membership dues or fees dedicated to helping alcoholics peer to peer in sobriety through its spiritually inclined Twelve Steps programme. Structurally guided by its Twelve Traditions, AA is non-professional, non-denominational, self-supporting and apolitical, an avowed desire to stop drinking is its sole requirement for membership. It has not endorsed the disease model of alcoholism, to which its programme is nonetheless sympathetic, but its wider acceptance is partly due to many AA members independently promulgating it. As of 2020, having spread to diverse cultures, including geopolitical areas normally resistant to grassroots movements, AA has had an estimated worldwide membership of over two million with 75% of those in the US and Canada.

Dr Alex: Our Young Mental Health Crisis (2021)

Introduction

Dr Alex George explores the wide range of mental health issues children and young people are facing, and finds out how projects funded by Children in Need are making a difference.

Outline

Dr Alex George follows the journeys of young people across the UK who are living with mental health issues. He explores the wide range of difficulties they face and finds out how local charities, including projects funded by Children in Need, are making a difference.

As an A&E doctor and the UK Youth Mental Health Ambassador, Alex has seen at first hand the effects of the pandemic on young people’s mental wellbeing, but he never thought they would affect his own family. But in July 2020, Alex’s 19-year-old brother Llyr, who had been struggling with anxiety during lockdown, took his own life. This poignant film is his response.

Production & Filming Details

  • Presenter(s):
    • Alex George.
  • Director(s):
    • Candace Davies.
  • Producer(s):
    • Becky Houlihan … producer.
    • Peter Wallis-Tayler … executive producer.
  • Writer(s):
  • Music:
  • Cinematography:
  • Editor(s):
  • Production:
    • Dragonfly Film and Television.
  • Distributor(s):
    • BBC.
  • Release Date: 14 November 2021.
  • Running Time: 59 minutes.
  • Rating: Unknown.
  • Country: UK.
  • Language: English.

Mnemophrenia (2019)

Introduction

Mnemophrenia is a futuristic drama about a new psychosis that arises from advanced virtual reality technology, which causes people to be unable to distinguish between real and artificial memories.

Outline

The film explores how society is affected by and how it adapts to deal with Mnemophrenia, a growing new psychosis and the still advancing technology. We see the story unfold over time, through the eyes of three generations of the same family who are all affected and involved in different ways. The story explores how attitudes to Mnemophrenia would differ from person to person and across generations, going from resistance and fear, through acceptance and eventually even using it to our benefit, pushing humanity towards a new evolutionary step.

Cast

  • Freya Berry … Jeanette Harper.
  • Robin King … Nicholas Morgan.
  • Tim Seyfert … Douglas.
  • Tallulah Sheffield … Robyin.
  • Jamie Laird … Will Hall.
  • Robert Milton Wallace … Charlie.
  • Dominic O’Flynn … Michael Murphy.
  • Angela Peters … Keri Taylor.
  • Anna Brook … Nina.
  • Michael Buckster … Richard.
  • Gary Cargill … Jim.
  • Steve Hope Wynne … David Quinn.
  • Lisa Caruccio Came … Anna Lyons.
  • Cally Lawrence … Tessa Fox.
  • John Morton … Self.

Trivia

  • The word ‘mnemophrenia’ was coined especially for the film.
    • It is a portmanteau of the words ‘mneme’ and ‘schizophrenia’.
    • In the film ‘Mnemophrenia’ the word is defined as: ‘A condition or a state characterised by the coexistence of real and artificial memories, which affects the subject’s sense of identity.’
  • The director, Eirini Konstantinidou, used improvisation in order to build the characters and the shooting script for the whole film.
    • She believes that the realistic dialogue and performances that are achieved through improvisation contribute to the intended blurring of the distinction between reality and fiction.
    • Part 1 needed to be made first and edited in order for the actors of the following period (part 2) to watch it and build their characters’ experiences from what they have watched; according to the premise of the film these video recordings become part of their memories and identity.
    • That is the process that the actors of part 3 had to go through as well.
    • This technique allows for an organic development of the characters and dialogue, which is a result of the creative collaboration between the actors and herself.

Production & Filming Details

  • Director(s):
    • Eirini Konstantinidou.
  • Producer(s):
    • Robin King … assistant producer.
    • Eirini Konstantinidou … producer.
  • Writer(s):
    • Eirini Konstantinidou … (writer).
    • Robin King … (co-writer).
    • Eirini Konstantinidou … (original story).
    • Gary Cargill … (additional material).
    • Cally Lawrence … (additional material).
    • Robert Milton Wallace … (additional material).
    • Freya Berry … (additional material).
    • Michael Buckster … (additional material).
    • Tallulah Sheffield … (additional material).
    • Tim Seyfert … (additional material).
    • Angela Peters … (additional material).
    • Anna Brook … (additional material).
    • Dominic O’Flynn … (additional material).
    • Jamie Laird … (additional material).
    • Lisa Came … (additional material).
  • Music:
    • Corey Zack.
  • Cinematography:
    • Mirko Beutler … (part one: “The Beginning”).
    • Petros Nousias … (part three: “Homo Mnemonicus”).
    • Richard Thomas … (part two: “Total Cinema”).
  • Editor(s):
    • Giorgio Galli.
  • Production:
    • EK Productions.
    • Quoxel.
  • Distributor(s):
    • Indie Rights (2019) (World-wide) (all media).
  • Release Date: 11 February 2019 (US, Boston Science Fiction Film Festival).
  • Running Time: 78 minutes.
  • Rating: Unknown.
  • Country: US.
  • Language: English.

Stacey Dooley: Back on the Psych Ward (2021)

Introduction

Stacey Dooley returns to Springfield Hospital to work with the team again, looking after patients over six months as they battle through the pandemic.

Refer to Stacey Dooley: On the Psych Ward (2020).

Outline

Mental health across society has worsened since the pandemic began. Stacey Dooley returns to Springfield Hospital, and over six months, including the second nationwide lockdown, works with the team to experience first-hand how the pandemic is impacting patients in crisis. Stacey assists staff as they treat a wide range of mental health conditions and takes part in the tough decisions necessary to keep patients safe.

Stacey meets Coral, who is brought into Springfield by the police one night after attempting to take her life. Coral tells Stacey and the team about her long-running battle with anxiety and depression, which she attempts to self-medicate by drinking alcohol.

The pandemic has seen a rise in suicidal behaviour, especially amongst young people. Stacey meets Oskar, a 20-year-old university student whose struggle with intense suicidal thoughts brings him into the hospital in crisis.

For those with pre-existing mental health conditions, waiting lists and delays to treatment caused by the pandemic are pushing them to breaking point. Suziee is diagnosed with emotionally unstable personality disorder, which causes extreme highs and lows to her moods. But with her therapy now cancelled, she is struggling to cope on her own and turns to the hospital for help.

Stacey also gets to know 21-year-old Ali, an inpatient at Springfield, which is home to the only inpatient unit of its kind in the country for those with severe obsessive compulsive disorder (OCD). Since childhood, Ali’s OCD rituals have changed from repetitive tapping during stressful exams and blinking to keep her parents safe in the car to extreme bathroom routines. For severe OCD cases like Ali’s, this ward is her last chance at beating this devastating condition, and over the months Stacey sees a dramatic change in Ali’s obsessions.

Production & Filming Details

  • Presenter(s):
    • Stacey Dooley.
  • Director(s):
    • Erica Jenkin.
    • Katie Rice.
  • Producer(s):
    • Gabi Adams … assistant producer.
    • Carla Grande … producer.
    • Erica Jenkin … producer.
    • Katie Rice … producer.
    • Brian Woods … producer.
  • Writer(s):
  • Music:
    • Alexander Parsons.
  • Cinematography:
  • Editor(s):
    • Paddy Garrick.
  • Production:
    • True Vision.
  • Distributor(s):
    • BBC Three (2021) (UK) (video).
  • Release Date: 13 April 2021 (Internet).
  • Running Time: 59 minutes.
  • Rating: TV-MA.
  • Country: UK.
  • Language: English.

What is Olanzapine/Fluoxetine?

Introduction

Olanzapine/fluoxetine (trade name Symbyax, created by Eli Lilly and Company) is a fixed-dose combination medication containing olanzapine (Zyprexa), an atypical antipsychotic, and fluoxetine (Prozac), a selective serotonin reuptake inhibitor (SSRI). Olanzapine/fluoxetine is primarily used to treat the depressive episodes of bipolar I disorder as well as treatment-resistant depression.

Medical Uses

Olanzapine/fluoxetine was approved by the US Food and Drug Administration (FDA) to treat the depressive episodes of bipolar I disorder in 2003. In 2009, it was granted approval for the treatment of treatment-resistant depression.

Olanzapine/fluoxetine, or other antidepressant/antipsychotic combinations, are sometimes prescribed off-label for anxiety disorders, eating disorders, obsessive-compulsive disorder (OCD), and posttraumatic stress disorder (PTSD).

Side Effects

Possible side effects of olanzapine/fluoxetine include all those of the two component drugs: olanzapine (side effects) and fluoxetine (side effects). Common side effects include suicidal thoughts, increased appetite, weight gain, drowsiness, fatigue, dry mouth, swelling, tremor, blurred vision, and difficulty concentrating.

Olanzapine/fluoxetine could produce a severe allergic reaction and should not be used if the patient has previously experienced an allergic reaction to either fluoxetine or olanzapine.

Olanzapine is correlated with an increase in blood sugar. Patients with diabetes, or those at risk for developing it, require careful monitoring.

In rare cases, olanzapine/fluoxetine may cause neuroleptic malignant syndrome.

Like other SSRIs, olanzapine/fluoxetine carries a boxed warning stating that it could increase the risk of suicidal thoughts and behaviours in patients aged 24 and under. The warning also states that olanzapine/fluoxetine may increase the risk of death in elderly patients with dementia-related psychosis.

On This Day … 15 November

People (Deaths)

  • 1917 – Émile Durkheim, French sociologist, psychologist, and philosopher (b. 1858).

Emile Durkheim

David Émile Durkheim (15 April 1858 to 15 November 1917) was a French sociologist. He formally established the academic discipline of sociology and, with Max Weber, and Karl Marx, is commonly cited as the principal architect of modern social science.

From his lifetime, much of Durkheim’s work was concerned with how societies could maintain their integrity and coherence in modernity, an era in which traditional social and religious ties are no longer assumed, and in which new social institutions have come into being. Durkheim asserted that sociology is unique from other disciplines, such as psychology, because of its larger scale. Some tools that could be used in sociology are polls, surveys, statistics, and observing historical patients. Durkheim used these scientific tools in his analysis of suicides in Catholic and Protestant groups. His work was the concept of modern sociology. His first major sociological work was De la division du travail social (1893; The Division of Labour in Society), followed in 1895 by Les Règles de la Méthode Sociologique (The Rules of Sociological Method), the same year in which Durkheim set up the first European department of sociology and become France’s first professor of sociology. Durkheim’s seminal monograph, Le Suicide (1897), a study of suicide rates in Catholic and Protestant populations, especially pioneered modern social research, serving to distinguish social science from psychology and political philosophy. The following year, in 1898, he established the journal L’Année Sociologique. Les formes élémentaires de la vie religieuse (1912; The Elementary Forms of the Religious Life) presented a theory of religion, comparing the social and cultural lives of aboriginal and modern societies.

Durkheim was also deeply preoccupied with the acceptance of sociology as a legitimate science. He refined the positivism originally set forth by Auguste Comte, promoting what could be considered as a form of epistemological realism, as well as the use of the hypothetico-deductive model in social science. For Durkheim, sociology was the science of institutions, understanding the term in its broader meaning as the “beliefs and modes of behaviour instituted by the collectivity,” with its aim being to discover structural social facts. As such, Durkheim was a major proponent of structural functionalism, a foundational perspective in both sociology and anthropology. In his view, social science should be purely holistic, in that sociology should study phenomena attributed to society at large, rather than being limited to the specific actions of individuals.

He remained a dominant force in French intellectual life until his death in 1917, presenting numerous lectures and published works on a variety of topics, including the sociology of knowledge, morality, social stratification, religion, law, education, and deviance. Durkheimian terms such as “collective consciousness” have since entered the popular lexicon.

Bipolarised: Rethinking Mental Illness (2014)

Introduction

Bipolarised: Rethinking Mental Illness is a 2014 documentary by director Rita Kotzia.

Challenges conventional wisdom about mental illness and drug therapy through the raw personal journey of a man diagnosed as bipolar.

Outline

This documentary is about one man’s personal journey to heal. Diagnosed with bipolar disorder, Ross’ psychiatrist told him he would live with the disorder for the rest of his life and that he would have to take lithium to control symptoms. To Ross, taking the drug daily felt like a chemical lobotomy, leaving him in a foggy, drug-induced haze. Ross ultimately decided to resolve his symptoms outside of conventional medicine. He progressively reduced his use of the psychotropic drug lithium, at an experimental clinic in Costa Rica. What ensued was a self-exploration into alternative treatments to treat his condition and a journey delving into the root cause of his mental breakdown. The film uses Ross’ personal experiences to tell a larger story about medication. It will reveal how we are labelling more and more people with mental illnesses and how, in tandem, we are prescribing more and more toxic psychotropic drugs to treat these illnesses. It weaves together a series of interviews with activists, psychiatrists and other psychiatric survivors who have challenged the status quo as well as recounts some of the alternative therapies Ross uses to maintain his mental, emotional and physical health.

Cast

  • Ross McKenzie … Self.
  • David Goldbloom … Self / Professor of Psychiatry.
  • Peter Levine … Self / Writer.
  • Gwen Olsen … Self / Pharmaceutical rep.
  • Charles Whitfield … Self / Psychotherapist.
  • Robert Whittaker … Self / Journalist.

Production & Filming Details

  • Director(s):
    • Rita Kotzia.
  • Producer(s):
    • Noelle Kim Chalifoux … producer.
    • Gordon Henderson … producer.
    • Rita Kotzia … producer.
  • Writer(s):
    • Gordon Henderson … (writer).
    • Rita Kotzia … (writer).
  • Music:
  • Cinematography:
  • Editor(s):
  • Production:
  • Distributor(s):
  • Release Date: April 2014.
  • Running Time: 77 minutes.
  • Rating: TV-MA.
  • Country: Canada.
  • Language: English.

32 Pills: My Sister’s Suicide (2017)

Introduction

She’s beautiful, artistic, loved and can’t stand to be alive. 32 PILLS traces the fascinating life and mental illness of my sister, New York artist and photographer Ruth Litoff, and my struggle to come to terms with her tragic suicide.

Outline

After struggling with mental illness for most of her life, New York artist Ruth Litoff committed suicide at age 42 in 2008 by overdosing on prescription pills. Six years later, her younger sister, Hope Litoff, decides to film herself while she empties a packed-to-the-brim storage unit filled with Ruth’s belongings, driven by the need to understand Ruth’s illness and desire to end her life – but as she pores through the items her sister left behind, she must exorcise the demons that threaten her sobriety.

Read the rest of the HBO synopsis here.

Cast

  • Ruth Litoff as self.
  • Hope Litoff as Self.

Production & Filming Details

  • Director(s):
    • Hope Litoff.
  • Producer(s):
    • Dan Cogan … executive producer.
    • Steven H. Cohen … co-executive producer.
    • Paula M. Froehle … co-executive producer.
    • Lise King … social impact producer.
    • Beth Levison … producer.
    • Sheila Nevins … executive producer.
    • Regina K. Scully … executive producer (as Regina Kulik Scully).
  • Writer(s):
  • Music:
    • Todd Griffin.
  • Cinematography:
    • Daniel B. Gold.
  • Editor(s):
    • Toby Shimin.
  • Production:
    • HBO Documentary Films.
  • Distributor(s):
    • Home Box Office (HBO) (2016) (USA) (TV).
  • Release Date: 01 May 2017 (Canada, Hot Docs International Documentary Festival).
  • Running Time: 89 minutes.
  • Rating: TV-MA.
  • Country: US.
  • Language: English.